{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T14:29:17Z","timestamp":1785680957066,"version":"3.56.0"},"reference-count":71,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2008,2,26]],"date-time":"2008-02-26T00:00:00Z","timestamp":1203984000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2008,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Primary laryngeal small cell neuroendocrine carcinoma (SCNC) is an unusual malignancy accounting for &lt;0.5% of laryngeal carcinomas. To date, approximately 200 cases of primary and 5 of secondary SCNC of the larynx have been reported. This tumor most often presents in the sixth and seventh decades in men who are heavy cigarette smokers. The lesion may be associated with different paraneoplastic syndromes (ectopic adrenocorticotropic hormone syndrome, Schwartz\u2013Bartter syndrome or syndrome of inappropriate secretion of antidiuretic hormone, and Eaton\u2013Lambert myasthenic syndrome) or with ectopic hormone production. The diagnosis is based essentially on the histologic appearance of the tumor, confirmed by immunocytochemical investigations. Concurrent chemoradiotherapy regimens offer potential for long\u2010term survival. This tumor is biologically aggressive, and the extent of the disease is the most significant independent prognostic factor of survival. The survival rate is similar to that with pulmonary SCNC. \u00a9 2008 Wiley Periodicals, Inc. Head Neck, 2008<\/jats:p>","DOI":"10.1002\/hed.20797","type":"journal-article","created":{"date-parts":[[2008,2,27]],"date-time":"2008-02-27T00:16:27Z","timestamp":1204071387000},"page":"518-524","source":"Crossref","is-referenced-by-count":65,"title":["Primary and secondary small cell neuroendocrine carcinoma of the larynx: A review"],"prefix":"10.1002","volume":"30","author":[{"given":"Alfio","family":"Ferlito","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Rinaldo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,2,26]]},"reference":[{"key":"e_1_2_13_2_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminoncol.2006.10.027"},{"key":"e_1_2_13_3_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminoncol.2006.10.023"},{"key":"e_1_2_13_4_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminoncol.2006.10.024"},{"key":"e_1_2_13_5_2","first-page":"590","article-title":"Extrapulmonary small cell carcinoma\u2014a medical center's experience","volume":"29","author":"Huang TL","year":"2006","journal-title":"Chang Gung Med J"},{"key":"e_1_2_13_6_2","first-page":"1131","article-title":"Extrapulmonary small cell carcinoma in 52 patients","volume":"25","author":"Yuan ZY","year":"2006","journal-title":"Ai Zheng"},{"key":"e_1_2_13_7_2","first-page":"771","article-title":"Clinical analysis of 33 cases of primary esophageal small cell carcinoma","volume":"26","author":"Duan HB","year":"2007","journal-title":"Ai Zheng"},{"key":"e_1_2_13_8_2","doi-asserted-by":"publisher","DOI":"10.1080\/00016480500401027"},{"key":"e_1_2_13_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0194-5998(95)70131-1"},{"key":"e_1_2_13_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.1984.tb01449.x"},{"key":"e_1_2_13_11_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.02.130"},{"key":"e_1_2_13_12_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215105003099"},{"key":"e_1_2_13_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2006.01.002"},{"key":"e_1_2_13_14_2","doi-asserted-by":"publisher","DOI":"10.1177\/000348948909801006"},{"key":"e_1_2_13_15_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100141830"},{"key":"e_1_2_13_16_2","first-page":"57","article-title":"Neuroendocrine tumors of the larynx","volume":"1","author":"Il'in AA","year":"2007","journal-title":"Vestn Otorinolaringol"},{"key":"e_1_2_13_17_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2005-870506"},{"key":"e_1_2_13_18_2","first-page":"615","article-title":"Neuroendocrine laryngeal cancers","volume":"60","author":"Jordan J","year":"2006","journal-title":"Otolaryngol Pol"},{"key":"e_1_2_13_19_2","doi-asserted-by":"publisher","DOI":"10.1159\/000276220"},{"key":"e_1_2_13_20_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.04.8736"},{"key":"e_1_2_13_21_2","doi-asserted-by":"publisher","DOI":"10.1177\/014556130608501106"},{"key":"e_1_2_13_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.22235"},{"key":"e_1_2_13_23_2","first-page":"573","article-title":"High grade intermediate cell neuroendocrine cancer of the larynx\u2014case report","volume":"27","author":"Dutsch\u2010Wicherek M","year":"2006","journal-title":"Neuro Endocrinol Lett"},{"key":"e_1_2_13_24_2","doi-asserted-by":"publisher","DOI":"10.1080\/02841860601071893"},{"key":"e_1_2_13_25_2","doi-asserted-by":"publisher","DOI":"10.1159\/000072249"},{"key":"e_1_2_13_26_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100123709"},{"key":"e_1_2_13_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2006.09.011"},{"key":"e_1_2_13_28_2","doi-asserted-by":"publisher","DOI":"10.1177\/014107688908201122"},{"key":"e_1_2_13_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/0278-2391(89)90014-1"},{"key":"e_1_2_13_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-0709(98)90112-0"},{"key":"e_1_2_13_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(84)90368-2"},{"key":"e_1_2_13_32_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100083110"},{"key":"e_1_2_13_33_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2230.1999.00445.x"},{"key":"e_1_2_13_34_2","first-page":"4187","article-title":"Gingival metastasis as initial presentation of small cell carcinoma of the lung","volume":"23","author":"Aoe K","year":"2003","journal-title":"Anticancer Res"},{"key":"e_1_2_13_35_2","first-page":"74","article-title":"Metastasi solitaria al laringe da microcitoma polmonare","volume":"79","author":"Bolla A","year":"1968","journal-title":"Arch Ital Otol"},{"key":"e_1_2_13_36_2","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1978.00790030054014"},{"key":"e_1_2_13_37_2","first-page":"105","article-title":"Metastasi alla laringe da neoplasie primitive sistemiche. Revisione critica","volume":"63","author":"Radici M","year":"1988","journal-title":"Valsalva"},{"key":"e_1_2_13_38_2","first-page":"203","article-title":"Metastasi laringea solitaria di carcinoma a piccole cellule polmonari \u201ccosiddetto microcitoma\u201d. Descrizione di un caso clinico","volume":"65","author":"Fiaoni M","year":"1989","journal-title":"Valsalva"},{"key":"e_1_2_13_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/0090-4295(90)80320-M"},{"key":"e_1_2_13_40_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19870515)59:10<1803::AID-CNCR2820591019>3.0.CO;2-X"},{"key":"e_1_2_13_41_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00185390"},{"key":"e_1_2_13_42_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19830501)51:9<1731::AID-CNCR2820510929>3.0.CO;2-6"},{"key":"e_1_2_13_43_2","first-page":"349","article-title":"Syndrome de Schwartz\u2013Bartter: r\u00e9v\u00e9lateur d'un cancer laryng\u00e9 sousglottique \u00e0 petites cellules","volume":"96","author":"Trotoux J","year":"1979","journal-title":"Ann Otolaryngol Chir Cervicofac"},{"key":"e_1_2_13_44_2","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1984.00800280057017"},{"key":"e_1_2_13_45_2","first-page":"915","article-title":"Multiple hormone production in an oat cell carcinoma of the larynx","volume":"35","author":"Bishop JW","year":"1985","journal-title":"Acta Pathol Jpn"},{"key":"e_1_2_13_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0385-8146(89)80044-6"},{"key":"e_1_2_13_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0194-5998(95)70124-9"},{"key":"e_1_2_13_48_2","doi-asserted-by":"publisher","DOI":"10.1177\/000348940711600705"},{"key":"e_1_2_13_49_2","first-page":"263","article-title":"Neuroendocrine neoplasms in unusual primary sites","volume":"4","author":"Gould VE","year":"1981","journal-title":"Diagn Histopathol"},{"key":"e_1_2_13_50_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1008099"},{"key":"e_1_2_13_51_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-198511000-00001"},{"key":"e_1_2_13_52_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.1711500302"},{"key":"e_1_2_13_53_2","first-page":"809","article-title":"A comparison of paraganglioma, carcinoid tumor, and small\u2010cell carcinoma of the larynx","volume":"112","author":"Googe PB","year":"1988","journal-title":"Arch Pathol Lab Med"},{"key":"e_1_2_13_54_2","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.5858\/2004-128-1279-PCSASC","article-title":"Primary combined squamous and small cell carcinoma of the larynx: a case report and review of the literature","volume":"128","author":"Jaiswal VR","year":"2004","journal-title":"Arch Pathol Lab Med"},{"key":"e_1_2_13_55_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-006-0060-8"},{"key":"e_1_2_13_56_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2004.12.005"},{"key":"e_1_2_13_57_2","doi-asserted-by":"publisher","DOI":"10.1159\/000276158"},{"key":"e_1_2_13_58_2","doi-asserted-by":"publisher","DOI":"10.1080\/00016480410016540"},{"key":"e_1_2_13_59_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2007.02.001"},{"key":"e_1_2_13_60_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2006.11.011"},{"key":"e_1_2_13_61_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-198711000-00004"},{"key":"e_1_2_13_62_2","doi-asserted-by":"publisher","DOI":"10.1002\/hed.2880160310"},{"key":"e_1_2_13_63_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0385-8146(86)80007-4"},{"key":"e_1_2_13_64_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.11795"},{"key":"e_1_2_13_65_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.anl.2005.09.002"},{"key":"e_1_2_13_66_2","doi-asserted-by":"publisher","DOI":"10.1002\/hed.2890080505"},{"key":"e_1_2_13_67_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.22887"},{"key":"e_1_2_13_68_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2003.09.017"},{"key":"e_1_2_13_69_2","volume-title":"Atlas of tumor pathology","author":"Colby TV","year":"1995"},{"key":"e_1_2_13_70_2","volume-title":"Ackerman's surgical pathology","author":"Rosai J","year":"1996"},{"key":"e_1_2_13_71_2","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3880522"},{"key":"e_1_2_13_72_2","doi-asserted-by":"publisher","DOI":"10.1053\/sonc.2003.50011"}],"container-title":["Head &amp; Neck"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhed.20797","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.20797","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,8]],"date-time":"2023-10-08T20:54:43Z","timestamp":1696798483000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hed.20797"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,2,26]]},"references-count":71,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2008,4]]}},"alternative-id":["10.1002\/hed.20797"],"URL":"https:\/\/doi.org\/10.1002\/hed.20797","archive":["Portico"],"relation":{},"ISSN":["1043-3074","1097-0347"],"issn-type":[{"value":"1043-3074","type":"print"},{"value":"1097-0347","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,2,26]]}}}