{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T15:55:09Z","timestamp":1787500509457,"version":"build-2736575974"},"reference-count":31,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2008,3,7]],"date-time":"2008-03-07T00:00:00Z","timestamp":1204848000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2008,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Head and neck solitary extramedullary plasmacytomas are rare plasma cell neoplasms. Literature review reveals only small numbers of reports. The objective was to review our experience with treating patients with this neoplasm.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective chart review between 1960 and 2000 was performed. Sixty\u2010eight patients with head and neck extramedullary plasmacytomas were included.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The sinonasal tract was the most common site. Thirty\u2010nine patients were treated with radiation, 8 with surgery, 14 with surgery and radiation, and 3 with chemoradiation. Median follow\u2010up was 8 years. The 5\u2010year local recurrence\u2013free rate (LRFR) was 81%. There was a trend toward improved LRFR in patients treated primarily with radiation. Regional recurrence at 5 years was 5%. Multiple myeloma developed in 23% of patients. The 5\u2010year survival was 76%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Radiation is the treatment of choice with surgery reserved for large tumors and extensive bone destruction. Long\u2010term follow\u2010up is essential because local recurrence and disseminated disease can occur many years postdiagnosis. \u00a9 2008 Wiley Periodicals, Inc. Head Neck, 2008<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hed.20821","type":"journal-article","created":{"date-parts":[[2008,3,7]],"date-time":"2008-03-07T14:55:52Z","timestamp":1204901752000},"page":"1012-1019","source":"Crossref","is-referenced-by-count":122,"title":["Solitary extramedullary plasmacytoma of the head and neck\u2014Long\u2010term outcome analysis of 68 cases"],"prefix":"10.1002","volume":"30","author":[{"given":"Gideon","family":"Bachar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Goldstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dale","family":"Brown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Tsang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gina","family":"Lockwood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bayardo","family":"Perez\u2010Ordonez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Irish","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,3,7]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.suronc.2005.05.001"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19990601)85:11<2305::AID-CNCR2>3.0.CO;2-3"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1997.162"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-197605000-00002"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2005.06.039"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-198209000-00004"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197208)30:2<414::AID-CNCR2820300217>3.0.CO;2-Z"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0167-8140(90)90003-F"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1995.26"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100083626"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197903)43:3<1007::AID-CNCR2820430333>3.0.CO;2-4"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/hed.2890090610"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1983.1.4.255"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000421-198706000-00004"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(02)02780-3"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2004.04834.x"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(00)01572-8"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-9260(81)80242-5"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-9260(65)80088-5"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197906)43:6<2340::AID-CNCR2820430625>3.0.CO;2-M"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(77)90054-2"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2005.09.019"},{"key":"e_1_2_5_24_2","doi-asserted-by":"publisher","DOI":"10.1177\/000348948309200320"},{"key":"e_1_2_5_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19870415)59:8<1475::AID-CNCR2820590814>3.0.CO;2-2"},{"key":"e_1_2_5_26_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00253117"},{"key":"e_1_2_5_27_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.annonc.a058070"},{"key":"e_1_2_5_28_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19920315)69:6<1513::AID-CNCR2820690633>3.0.CO;2-X"},{"key":"e_1_2_5_29_2","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1964.00750030626010"},{"key":"e_1_2_5_30_2","first-page":"83","article-title":"Extramedullary plasmacytoma","volume":"32","author":"Dolin S","year":"1956","journal-title":"Am J Pathol"},{"key":"e_1_2_5_31_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.annonc.a059285"},{"key":"e_1_2_5_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-8140(99)00114-0"}],"container-title":["Head &amp; 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