{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T13:41:50Z","timestamp":1783950110823,"version":"3.55.0"},"reference-count":48,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2008,6,4]],"date-time":"2008-06-04T00:00:00Z","timestamp":1212537600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2008,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Since the introduction of endoscopic laser surgery at our institution in 1996, 189 patients have been treated for T1 glottic carcinoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Treatment allocation (radiotherapy vs laser surgery) and outcome were evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifty\u2010one percent of T1a lesions were considered suitable for laser surgery. Sixteen percent of T1a patients treated with laser surgery needed additional treatment because of positive resection margins. Overall local control and larynx preservation were 89% and 96%. Both were poorer in T1a patients with larger lesions treated with radiotherapy (local control 75% versus 89%, <jats:italic>p<\/jats:italic> = .05, larynx preservation 83% vs 100%, <jats:italic>p<\/jats:italic> = .001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Outcome for T1a patients selected for laser surgery is excellent. In patients with larger lesions treated with radiotherapy, outcome is inferior to patients selected for laser surgery, but also to that reported for (unselected) T1a carcinomas treated with radiotherapy in literature. Strategies to improve treatment results in patients deemed unsuitable for laser surgery should be designed. \u00a9 2008 Wiley Periodicals, Inc. Head Neck, 2008<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.20852","type":"journal-article","created":{"date-parts":[[2008,6,4]],"date-time":"2008-06-04T21:53:48Z","timestamp":1212616428000},"page":"1167-1174","source":"Crossref","is-referenced-by-count":47,"title":["Clinical outcome of T1 glottic carcinoma since the introduction of endoscopic CO<sub>2<\/sub> laser surgery as treatment option"],"prefix":"10.1002","volume":"30","author":[{"given":"Elisabeth V.","family":"Sj\u00f6gren","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ton P. M.","family":"Langeveld","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert J.","family":"Baatenburg de Jong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,6,4]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2273.2000.00347.x"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1520-6823(1999)7:1<42::AID-ROI6>3.0.CO;2-W"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2005.05.018"},{"key":"e_1_2_5_5_2","first-page":"169","article-title":"Radiation therapy for early glottic carcinoma (T1N0M0). The final results of prospective randomized study concerning radiation field","volume":"172","author":"Chatani M","year":"1996","journal-title":"Strahlenther Onkol"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(00)00635-0"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2005.10.010"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(02)02920-6"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(97)00284-8"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2001.19.20.4029"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-8140(97)00196-5"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(93)90490-M"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(98)00375-7"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.183.3.1584935"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(91)90274-8"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(98)00226-0"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2005.06.014"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(96)00578-0"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(98)00547-1"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2001.19.20.4029"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1177\/019459989310800605"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-997167"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1177\/000348949210100202"},{"key":"e_1_2_5_24_2","first-page":"250","article-title":"Transoral laser surgery of laryngeal carcinomas. State of the art in Sweden","volume":"49","author":"Lindholm CE","year":"1995","journal-title":"Adv Otorhinolaryngol"},{"key":"e_1_2_5_25_2","volume-title":"Abstractbook First International Workshop on Laser Surgery in ENT, State of the Art","author":"Mahieu HF","year":"1999"},{"key":"e_1_2_5_26_2","doi-asserted-by":"publisher","DOI":"10.1177\/000348949410300104"},{"key":"e_1_2_5_27_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00178101"},{"key":"e_1_2_5_28_2","doi-asserted-by":"publisher","DOI":"10.1177\/000348949009900108"},{"key":"e_1_2_5_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/0196-0709(93)90050-H"},{"key":"e_1_2_5_30_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200408000-00031"},{"key":"e_1_2_5_31_2","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1994.01880330035007"},{"key":"e_1_2_5_32_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-003-0697-5"},{"key":"e_1_2_5_33_2","doi-asserted-by":"publisher","DOI":"10.1177\/000348940311200212"},{"key":"e_1_2_5_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvoice.2004.03.001"},{"key":"e_1_2_5_35_2","doi-asserted-by":"publisher","DOI":"10.1002\/hed.20301"},{"key":"e_1_2_5_36_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200202000-00030"},{"key":"e_1_2_5_37_2","doi-asserted-by":"publisher","DOI":"10.1002\/hed.20266"},{"key":"e_1_2_5_38_2","doi-asserted-by":"publisher","DOI":"10.1177\/000348940411301101"},{"key":"e_1_2_5_39_2","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.132.2.147"},{"key":"e_1_2_5_40_2","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.129.6.623"},{"key":"e_1_2_5_41_2","first-page":"245","article-title":"Analysis of recurrences after transoral laser resection of larynx carcinomas","volume":"49","author":"Thumfart WF","year":"1995","journal-title":"Adv Otorhinolaryngol"},{"key":"e_1_2_5_42_2","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-199010000-00014"},{"key":"e_1_2_5_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0194-5998(98)70093-2"},{"key":"e_1_2_5_44_2","doi-asserted-by":"publisher","DOI":"10.1177\/000348940611500803"},{"key":"e_1_2_5_45_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2273.2004.00919.x"},{"key":"e_1_2_5_46_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004050050228"},{"key":"e_1_2_5_47_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-007-0279-z"},{"key":"e_1_2_5_48_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.MLG.0000217557.45491.BD"},{"key":"e_1_2_5_49_2","doi-asserted-by":"publisher","DOI":"10.1177\/000348940311200903"}],"container-title":["Head &amp; Neck"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhed.20852","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.20852","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T14:45:35Z","timestamp":1697467535000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hed.20852"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,6,4]]},"references-count":48,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2008,9]]}},"alternative-id":["10.1002\/hed.20852"],"URL":"https:\/\/doi.org\/10.1002\/hed.20852","archive":["Portico"],"relation":{},"ISSN":["1043-3074","1097-0347"],"issn-type":[{"value":"1043-3074","type":"print"},{"value":"1097-0347","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,6,4]]}}}