{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T07:32:26Z","timestamp":1767339146633},"reference-count":8,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2008,9,16]],"date-time":"2008-09-16T00:00:00Z","timestamp":1221523200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2009,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background.<\/jats:title><jats:p>Histoplasmosis is a localized or systemic fungal infection which may present as an acute primary or \u201creactivation\u201d infection in the setting of immunosuppression. Tumor necrosis factor alpha (TNF\u2010\u03b1) antagonists, used in the management of rheumatoid arthritis and Crohn disease, have been linked to reactivation of quiescent histoplasmosis. Microscopically, granulomas are either not evident or are infrequent in histoplasmosis when associated with TNF antagonist therapy presumably due to the suppression of macrophage activity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results.<\/jats:title><jats:p>This article describes an unusual presentation of oral histoplasmosis in a 75\u2010year\u2010old\u2010woman patient on TNF\u2010\u03b1 antagonist, namely infliximab. Microscopically, cellular atypia resulted in a work\u2010up to rule out lymphoma. Gomori's methenamine silver stain demonstrated <jats:italic>Histoplasma capsulatum<\/jats:italic> leading to a diagnosis of histoplasmosis. She was treated successfully with itraconozole.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion.<\/jats:title><jats:p>This is the first reported case, insofar as the authors are able to determine, of oral histoplasmosis, in a patient undergoing treatment with infliximab. \u00a9 2008 Wiley Periodicals, Inc. Head Neck, 2009<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.20882","type":"journal-article","created":{"date-parts":[[2008,9,16]],"date-time":"2008-09-16T20:39:25Z","timestamp":1221597565000},"page":"274-277","source":"Crossref","is-referenced-by-count":16,"title":["Oral histoplasmosis: An unusual presentation"],"prefix":"10.1002","volume":"31","author":[{"given":"Nagamani","family":"Narayana","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryan","family":"Gifford","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Giannini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Casey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,9,16]]},"reference":[{"key":"e_1_2_5_2_2","first-page":"2247","article-title":"Overview of histoplasmosis","volume":"66","author":"Kurowski R","year":"2002","journal-title":"Am Fam Physician"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1590\/S0036-46652006000200012"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1086\/383317"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2005.01.009"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2004.02571.x"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1086\/429998"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2006.02.001"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.22056"}],"container-title":["Head &amp; Neck"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhed.20882","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.20882","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T17:11:50Z","timestamp":1696957910000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hed.20882"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,9,16]]},"references-count":8,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2009,2]]}},"alternative-id":["10.1002\/hed.20882"],"URL":"https:\/\/doi.org\/10.1002\/hed.20882","archive":["Portico"],"relation":{},"ISSN":["1043-3074","1097-0347"],"issn-type":[{"value":"1043-3074","type":"print"},{"value":"1097-0347","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,9,16]]}}}