{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T09:02:21Z","timestamp":1792659741689,"version":"4.5.0"},"reference-count":73,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2008,8,14]],"date-time":"2008-08-14T00:00:00Z","timestamp":1218672000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2008,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background.<\/jats:title><jats:p>An evaluation of the treatment results for 104 patients with 121 paragangliomas of the temporal bone, carotid body, and\/or glomus vagale who were treated with radiation therapy (RT) at the University of Florida between 1968 and 2004.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods.<\/jats:title><jats:p>Eighty\u2010nine paragangliomas (86%) were treated with conventional megavoltage techniques, 15 (14%) patients with stereotactic fractionated radiation therapy, 6 (6%) patients with stereotactic radiosurgery (SRS), and 11 (11%) patients with intensity\u2010modulated radiation therapy (IMRT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results.<\/jats:title><jats:p>There were 6 local recurrences. One recurrence was salvaged with additional RT. The actuarial local control and cause\u2010specific survival rates at 10 years were 94% and 95%. The overall local control rate for all 121 lesions was 95%; the ultimate local control rate was 96%. The incidence of treatment\u2010related complications was low.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion.<\/jats:title><jats:p>Fractionated RT offers a high probability of tumor control with minimal risks for patients with paragangliomas of the temporal bone and neck. \u00a9 2008 Wiley Periodicals, Inc. Head Neck, 2008<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.20885","type":"journal-article","created":{"date-parts":[[2008,8,14]],"date-time":"2008-08-14T20:24:29Z","timestamp":1218745469000},"page":"1431-1438","source":"Crossref","is-referenced-by-count":137,"title":["Definitive radiotherapy in the management of paragangliomas arising in the head and neck: A 35\u2010year experience"],"prefix":"10.1002","volume":"30","author":[{"given":"Russell W.","family":"Hinerman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert J.","family":"Amdur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher G.","family":"Morris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Kirwan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William 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