{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T22:05:13Z","timestamp":1792188313067,"version":"4.4.0"},"reference-count":19,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2008,8,14]],"date-time":"2008-08-14T00:00:00Z","timestamp":1218672000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2008,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background.<\/jats:title><jats:p>Brown tumor occasionally affects the facial bones. Clinically, these lesions can be mistaken for a neoplasm. Opinions are divided on the course of management of the bony lesions once parathyroidectomy has been carried out.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods.<\/jats:title><jats:p>We treated 22 patients with primary hyperparathyroidism and osteitis fibrosa cystica and observed their clinical and biochemical recovery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results.<\/jats:title><jats:p>Fifteen patients (68.2%) had brown tumors in mandible, and 7 (31.8%) in maxilla. After parathyroidectomy, 21 patients had normal total serum calcium values. All brown tumors presented a spontaneous progressive regression; in 18cases, regression was total, with a mean time period of 10months. Two patients had partial regression after nearly 2years. Another 2 patients were lost to follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions.<\/jats:title><jats:p>After successful parathyroid surgery, the bony lesions tended to regress spontaneously, either partially or completely. However, if the lesion is disfiguring or symptomatic, surgical excision may be indicated. \u00a9 2008 Wiley Periodicals, Inc. Head Neck, 2008<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.20905","type":"journal-article","created":{"date-parts":[[2008,8,14]],"date-time":"2008-08-14T20:24:53Z","timestamp":1218745493000},"page":"1497-1504","source":"Crossref","is-referenced-by-count":53,"title":["Evolution of maxillofacial brown tumors after parathyroidectomy in primary hyperparathyroidism"],"prefix":"10.1002","volume":"30","author":[{"given":"Jaime Alonso","family":"Res\u00e9ndiz\u2010Colosia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio Arturo","family":"Rodr\u00edguez\u2010Cuevas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rutilio","family":"Flores\u2010D\u00edaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mart\u00edn Hern\u00e1ndez\u2010San","family":"Juan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Francisco","family":"Gallegos\u2010Hern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sinhu\u00e9","family":"Barroso\u2010Bravo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"G\u00f3mez\u2010Acosta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,8,14]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.4065\/77.1.87"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1067\/msy.2002.128693"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-005-0040-y"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.2004.01422.x"},{"key":"e_1_2_5_6_2","doi-asserted-by":"crossref","first-page":"5138","DOI":"10.1210\/jcem.86.11.7994","article-title":"Tc99m\u2010sestamibi uptake in osteitis fibrosa cystica simulating metastatic bone disease","volume":"86","author":"Rubin MR","year":"2001","journal-title":"J Clin Endocrinol Metab"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.0007-1323.2001.01775.x"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1177\/014556130508400714"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-0020.2000.290612.x"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1053\/joms.2001.27533"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1053\/joms.2003.50142"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF03347028"},{"key":"e_1_2_5_13_2","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.tripleo.2004.01.015","article-title":"Primary hyperparathyroidism presenting as a palatal brown tumor","volume":"98","author":"Daniel JS","year":"2004","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2004.02.011"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2005.11.004"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1067\/msy.2002.128484"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2796.2003.01168.x"},{"key":"e_1_2_5_18_2","first-page":"140","article-title":"Loss of nuclear expression of parafibromin distinguishes parathyroid carcinoma and hyperparathyroidism\u2010jaw tumor (HPT\u2010JT) syndrome\u2010related adenoma from sporadic parathyroid adenoma and hyperplasias","volume":"30","author":"Gill AJ","year":"2006","journal-title":"Am J Surg Pathol"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2006.08.007"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/hed.2890080509"}],"container-title":["Head &amp; 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