{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T07:10:59Z","timestamp":1697613059594},"reference-count":9,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2008,10,13]],"date-time":"2008-10-13T00:00:00Z","timestamp":1223856000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2009,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Angiosarcoma arising after radiation is described in breast cancer but occurs elsewhere. Here, we present an angiosarcoma of the neck occurring after curative chemoradiation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This is a case of angiosarcoma developing 5 years after curative therapy for T3N0 squamous cell carcinoma of the supraglottic larynx. Therapy consisted of 3 cycles of induction cisplatin\/5\u2010fluorouracil chemotherapy followed by radiotherapy. The patient did well until developing a rapidly progressive lesion of the left neck. Examination showed a 7\u2010cm mass and biopsy revealed angiosarcoma. CT scans assessed the local extent of the tumor and ruled out metastatic disease prior to initiating therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Therapy consisted of 4 cycles of paclitaxel chemotherapy. At completion, examination revealed mild induration of the neck with near\u2010complete resolution of the mass. Imaging confirmed this excellent response.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This rare therapy\u2010related second malignancy developed after curative larynx\u2010preserving treatment. Paclitaxel was an effective therapy in this setting. \u00a9 2008 Wiley Periodicals, Inc. Head Neck, 2009<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.20929","type":"journal-article","created":{"date-parts":[[2008,10,14]],"date-time":"2008-10-14T17:33:20Z","timestamp":1224005600000},"page":"829-832","source":"Crossref","is-referenced-by-count":0,"title":["Angiosarcoma developing after curative induction chemotherapy and radiotherapy for locally advanced squamous cell carcinoma of the larynx"],"prefix":"10.1002","volume":"31","author":[{"given":"Patrick J.","family":"Gagnon","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chad","family":"Galderisi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brandi R.","family":"Page","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John M.","family":"Holland","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,10,13]]},"reference":[{"key":"e_1_2_4_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199106133242402"},{"key":"e_1_2_4_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(194805)1:1<64::AID-CNCR2820010105>3.0.CO;2-W"},{"key":"e_1_2_4_4_2","first-page":"420","article-title":"Postmastectomy angiosarcoma","volume":"121","author":"Sternby NH","year":"1961","journal-title":"Acta Chir Scand"},{"key":"e_1_2_4_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000156664.04955.83"},{"key":"e_1_2_4_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1993.01880210061009"},{"key":"e_1_2_4_7_2","doi-asserted-by":"publisher","DOI":"10.1053\/joms.2002.33255"},{"key":"e_1_2_4_8_2","doi-asserted-by":"crossref","unstructured":"SchlemmerM ReichardtP VerweijJ et al.Paclitaxel in patients (pts) with advanced angiosarcomas. In JCO 2007 ASCO Annual Meeting Proceedings Part 1 2007;25 (18 Suppl):10033 (abstract).","DOI":"10.1200\/jco.2007.25.18_suppl.10033"},{"key":"e_1_2_4_9_2","first-page":"2926","article-title":"Clinicopathologic assessment of postradiation sarcomas: KIT as a potential treatment target","volume":"9","author":"Komdeur R","year":"2003","journal-title":"Clin Cancer Res"},{"key":"e_1_2_4_10_2","doi-asserted-by":"crossref","unstructured":"D'AdamoDR KeohanM SchuetzeS et al.Clinical results of a phase II study of sorafenib in patients (pts) with non\u2010GIST sarcomas (CTEP study #7060). In JCO 2007 ASCO Annual Meeting Proceedings Part 1 2007; 25 (18 Suppl):10001 (abstract).","DOI":"10.1200\/jco.2007.25.18_suppl.10001"}],"container-title":["Head &amp; Neck"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhed.20929","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.20929","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T04:57:18Z","timestamp":1697518638000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hed.20929"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,10,13]]},"references-count":9,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2009,6]]}},"alternative-id":["10.1002\/hed.20929"],"URL":"https:\/\/doi.org\/10.1002\/hed.20929","archive":["Portico"],"relation":{},"ISSN":["1043-3074","1097-0347"],"issn-type":[{"value":"1043-3074","type":"print"},{"value":"1097-0347","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,10,13]]}}}