{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T22:37:48Z","timestamp":1790980668696,"version":"4.1.0"},"reference-count":34,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2008,11,20]],"date-time":"2008-11-20T00:00:00Z","timestamp":1227139200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2009,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background.<\/jats:title><jats:p>The majority of ectopic adrenocorticotropic hormone (ACTH)\u2010secreting tumors are localized in the chest or abdomen. Occasionally, these tumors are found in the paranasal sinuses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods.<\/jats:title><jats:p>We present 2 unusual cases of ectopic ACTH syndrome whose ACTH\u2010secreting tumors were localized in the paranasal sinuses and describe their biochemical and radiological presentation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results.<\/jats:title><jats:p>The first patient had an ACTH\u2010secreting olphactory neuroblastoma originating in the ethmoid sinuses. The second patient had a clinical course and biochemical findings indistinguishable from pituitary ACTH\u2010dependent Cushing's syndrome, except for negative petrosal sinus sampling. Head imaging showed a \u201cpolyp\u201d in the left maxillary sinus\u2010secreting ACTH. Both patients went into remission following surgicalresection and recovered normal pituitary\u2010adrenal axis function.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion.<\/jats:title><jats:p>Ectopic ACTH secretion may originate from lesions in the paranasal sinuses. This accessible location allows for direct immunohistochemical diagnosis with ACTH staining. Surgical resection\/radiation therapy can result in complete remission of the disease and restoration of normal pituitary\u2010adrenal function. \u00a9 2008 Wiley Periodicals, Inc. 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