{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,16]],"date-time":"2026-08-16T07:59:21Z","timestamp":1786867161810,"version":"build-2736575974"},"reference-count":41,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2008,12,23]],"date-time":"2008-12-23T00:00:00Z","timestamp":1229990400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2009,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background.<\/jats:title><jats:p>Xerostomia is a serious morbidity of radiation treatment in head and neck cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods.<\/jats:title><jats:p>We conducted a prospective phase III multicenter randomized study comparing submandibular salivary gland transfer (SGT) procedure with pilocarpine during and for 3 months after XRT. Salivary flow (baseline, stimulated) and University of Washington Quality of Life Questionnaire (U of W QOL) scores were measured.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results.<\/jats:title><jats:p>An interim intent to treat analysis (120 patients) at 6 months shows superior results in SGT arm: median baseline salivary flow for SGT (0.04 mL\/minute) versus pilocarpine (0.01 mL\/minute), <jats:italic>p<\/jats:italic> = .001; median stimulated salivary flow (0.18 mL\/minute) for SGT versus (0.05 mL\/minute) for pilocarpine, <jats:italic>p<\/jats:italic> = .003. Scores (U of W QOL) for amount (<jats:italic>p<\/jats:italic> = .017) and consistency of saliva (<jats:italic>p<\/jats:italic> = .005) in favor of SGT leading to premature closure of study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions.<\/jats:title><jats:p>Submandibular SGT procedure is superior to pilocarpine in management of radiation\u2010induced xerostomia. \u00a9 2008 Wiley Periodicals, Inc. Head Neck, 2009<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.20961","type":"journal-article","created":{"date-parts":[[2008,12,23]],"date-time":"2008-12-23T19:25:26Z","timestamp":1230060326000},"page":"234-243","source":"Crossref","is-referenced-by-count":65,"title":["Phase III randomized study: Oral pilocarpine versus submandibular salivary gland transfer protocol for the management of radiation\u2010induced 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