{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T09:43:48Z","timestamp":1778924628968,"version":"3.51.4"},"reference-count":17,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2009,3,3]],"date-time":"2009-03-03T00:00:00Z","timestamp":1236038400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2009,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background.<\/jats:title><jats:p>To investigate the prognostic value of volumetric analysis in patients with stage III\u2013IVA hypopharyngeal cancer treated with concurrent chemoradiotherapy (CCRT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods.<\/jats:title><jats:p>Seventy\u2010six stage III\u2013IVA hypopharyngeal cancer patients without bulky lymph nodes were enrolled for a volumetric analysis. The pyriform sinus was the principal site of involvement in the 63 cases. All patients were allocated a course of CCRT. Tumor volume measurement was derived using separate calculations for the primary tumor volume (pGTV) and the nodal tumor volume (nGTV).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results.<\/jats:title><jats:p>The pGTV ranged from 3.8 to 152.4 mL (mean, 33.4 mL). The 3\u2010year cause\u2010specific survival (CSS) was 75% for those with a pGTV &lt;30 mL and 20% when the pGTV was \u226530 mL (<jats:italic>p<\/jats:italic> = .0001). Furthermore, the 3\u2010year primary tumor relapse\u2010free survival (PRFS) was 72% for those with a pGTV &lt;30 mL and 23% when the pGTV were \u226530 mL (<jats:italic>p<\/jats:italic> = .0001). The 3\u2010year PRFSs for &lt;30 mL and \u226530 mL were 74% and 25% for stage III disease (<jats:italic>p<\/jats:italic> = .01) and 65% and 22% for stage IVA tumors (<jats:italic>p<\/jats:italic> = .01), respectively. Multivariate analyses of the CSS revealed a single prognostic factor, namely pGTV &lt;30 mL versus \u226530 mL (<jats:italic>p<\/jats:italic> = .0001, hazard ratio 2.84). Multivariate analyses of the PRFS gave a similar finding, with a pGTV \u226530 mL (<jats:italic>p<\/jats:italic> = .0001, hazard ratio 2.55) being significant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion.<\/jats:title><jats:p>A patient's pGTV is a strong outcome predictor for hypopharyngeal cancer treatment using CCRT. Therefore, a selected group of patients, mainly those with tumor volumes &lt;30 mL should be considered for laryngeal preservation. \u00a9 2009 Wiley Periodicals, Inc. 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