{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T13:35:23Z","timestamp":1787924123699,"version":"build-2784847793"},"reference-count":23,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2009,3,3]],"date-time":"2009-03-03T00:00:00Z","timestamp":1236038400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2009,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background.<\/jats:title><jats:p>Clinical outcome of endoscopic CO<jats:sub>2<\/jats:sub> laser surgery and radiotherapy in early\u2010stage glottic laryngeal carcinoma is difficult to compare because of differences in treatment selection and patient groups. Therefore, we compared local control, overall survival, and laryngeal preservation in a homogenous group of patients with T1a glottic carcinoma with normal\/diminished mucosal wave treated with either CO<jats:sub>2<\/jats:sub> laser surgery or radiotherapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods.<\/jats:title><jats:p>Retrospective survival analysis was performed on 100 patients with T1a glottic carcinoma treated with CO<jats:sub>2<\/jats:sub> laser surgery (<jats:italic>n<\/jats:italic> = 49) or radiotherapy (<jats:italic>n<\/jats:italic> = 51), diagnosed at the University Medical Center Groningen between 1990 and 2004.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results.<\/jats:title><jats:p>No significant differences in local control and overall survival were found. Ultimate 5\u2010year laryngeal preservation was significantly better in the CO<jats:sub>2<\/jats:sub> laser surgery group (95% vs 77%, <jats:italic>p<\/jats:italic> = .043).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion.<\/jats:title><jats:p>Patients with T1a glottic carcinoma with normal\/diminished mucosal wave treated with CO<jats:sub>2<\/jats:sub> laser surgery had a significantly better laryngeal preservation rate than patients treated with radiotherapy. \u00a9 2009 Wiley Periodicals, Inc. Head Neck, 2009<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.21027","type":"journal-article","created":{"date-parts":[[2009,3,4]],"date-time":"2009-03-04T01:56:28Z","timestamp":1236131788000},"page":"759-764","source":"Crossref","is-referenced-by-count":92,"title":["Higher laryngeal preservation rate after CO<sub>2<\/sub> laser surgery compared with radiotherapy in T1a glottic laryngeal carcinoma"],"prefix":"10.1002","volume":"31","author":[{"given":"Michiel L.","family":"Schrijvers","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva L.","family":"van Riel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes A.","family":"Langendijk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederik G.","family":"Dikkers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ed","family":"Schuuring","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline E.","family":"van der Wal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard F.","family":"A. 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