{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:24:57Z","timestamp":1787063097601,"version":"build-2736575974"},"reference-count":11,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2009,4,9]],"date-time":"2009-04-09T00:00:00Z","timestamp":1239235200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2009,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The true involvement of the submandibular gland in primary oral cancer seems quite uncommon.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively reviewed the pathologic records of 342 patients with oral squamous cell carcinoma who underwent wide excision of primary oral cancer and simultaneous neck dissection from January 2000 to December 2003.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of the 383 submandibular glands, only 7 (1.8%) exhibited tumor involvement. Of them, 5 glands were involved by direct extension from the primary tumor. One gland showed local invasion from an adjacent involved lymph node in level I and 1 was from intraglandular lymph node metastasis. All of these 6 tumors with submandibular gland involvement were T4 disease (\n                      <jats:italic>p<\/jats:italic>\n                      = .0003) and the neck nodal status on each was more than N2b (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; .0001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The patients with early\u2010stage oral squamous cell carcinoma with preoperative N0 neck may be candidates for preservation of the submandibular gland. \u00a9 2009 Wiley Periodicals, Inc. Head Neck, 2009<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hed.21039","type":"journal-article","created":{"date-parts":[[2009,4,9]],"date-time":"2009-04-09T13:13:51Z","timestamp":1239282831000},"page":"877-881","source":"Crossref","is-referenced-by-count":46,"title":["Rare involvement of submandibular gland by oral squamous cell carcinoma"],"prefix":"10.1002","volume":"31","author":[{"given":"Tseng\u2010Cheng","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wu\u2010Chia","family":"Lo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenq\u2010Yuh","family":"Ko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei\u2010Jen","family":"Lou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsung\u2010Lin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng\u2010Ping","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,4,9]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-199802000-00009"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0347(199605\/06)18:3<242::AID-HED6>3.0.CO;2-#"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2006.02.017"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/hed.20109"},{"key":"e_1_2_6_6_2","first-page":"521","article-title":"Involvement of the submadibular region in epidermoid carcinoma of the mouth floor. Prospective study of 31 cases","volume":"49","author":"Junquera L","year":"2000","journal-title":"Minerva Stomatol"},{"key":"e_1_2_6_7_2","first-page":"193","volume-title":"AJCC cancer staging manual","author":"Kneisl JS","year":"2002"},{"key":"e_1_2_6_8_2","first-page":"330","article-title":"Zum Verstaendniss der Verbreitung\u2010smoeglichkeiten des Zungenkrebses","volume":"31","author":"Bartels P","year":"1907","journal-title":"Anat Anz"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2005.12.017"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.1985.0384"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200102000-00028"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000199888.02540.8c"}],"container-title":["Head &amp; Neck"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhed.21039","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.21039","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,13]],"date-time":"2023-11-13T21:08:19Z","timestamp":1699909699000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hed.21039"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,4,9]]},"references-count":11,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2009,7]]}},"alternative-id":["10.1002\/hed.21039"],"URL":"https:\/\/doi.org\/10.1002\/hed.21039","archive":["Portico"],"relation":{},"ISSN":["1043-3074","1097-0347"],"issn-type":[{"value":"1043-3074","type":"print"},{"value":"1097-0347","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,4,9]]}}}