{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T09:38:29Z","timestamp":1792057109830,"version":"4.4.0"},"reference-count":15,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2009,3,12]],"date-time":"2009-03-12T00:00:00Z","timestamp":1236816000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2009,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title><jats:italic>Background.<\/jats:italic><\/jats:title><jats:p>To investigate whether human papilloma virus (HPV)\u2010specific immune mechanisms can result in tumor clearance, we have created HPV+ and HPV\u2212 tonsil cells that form squamous cancers in immune\u2010competent mice. Here, we determine that an immune\u2010specific response can clear HPV+ tumor cells and the cellular requirements to mediate this tumor clearance.<\/jats:p><\/jats:sec><jats:sec><jats:title><jats:italic>Methods.<\/jats:italic><\/jats:title><jats:p>Through the benefit of this model, we use in vitro and in vivo methods to better understand how HPV+ cells are rejected.<\/jats:p><\/jats:sec><jats:sec><jats:title><jats:italic>Results.<\/jats:italic><\/jats:title><jats:p>The data show that an in vivo antigen\u2010specific antitumor response is generated to HPV+ transformed cells and that this response requires CD4+ and CD8+ cells to mount this antitumor response.<\/jats:p><\/jats:sec><jats:sec><jats:title><jats:italic>Conclusion.<\/jats:italic><\/jats:title><jats:p>The findings from this preclinical model will have implications not only in understanding human disease but also as a valuable model for testing immunotherapeutic strategies for HPV+ head and neck cancer. \u00a9 2009 Wiley Periodicals, Inc. 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