{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,14]],"date-time":"2023-11-14T02:40:14Z","timestamp":1699929614911},"reference-count":11,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2009,3,23]],"date-time":"2009-03-23T00:00:00Z","timestamp":1237766400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2009,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title><jats:italic>Background.<\/jats:italic><\/jats:title><jats:p>Our aim was to determine whether percutaneous endoscopic gastrostomy (PEG) dependence was significantly different between 2 prospective trials with different radiation fractionation schemes.<\/jats:p><\/jats:sec><jats:sec><jats:title><jats:italic>Methods.<\/jats:italic><\/jats:title><jats:p>Stage III or IV locally advanced head and neck squamous cell carcinomas arising from the oral cavity, hypopharynx, oropharynx, nasopharynx, paranasal sinuses, or larynx were treated using hyperfractionation (A\u20103 protocol) or accelerated fractionation (A\u20104 protocol) with chemotherapy. Amifostine was administered 15 to 30 minutes preradiation, at a dose of 500 mg\/day in both protocols. It was given as an infusion over 5 to 7 minutes (A\u20103 protocol) or subcutaneously (A\u20104 protocol). Data regarding PEG placement and removal were collected prospectively.<\/jats:p><\/jats:sec><jats:sec><jats:title><jats:italic>Results.<\/jats:italic><\/jats:title><jats:p>Thirty\u2010five evaluable A\u20103 protocol patients, 14 evaluable A\u20104 protocol patients, and 6 patients treated per A\u20104 protocol guidelines, but without amifostine as they refused the medication, were included in the analysis. Pretreatment characteristics, such as sex, age, race, T classification, N classification, American Joint Committee on Cancer (AJCC) stage, were compared between the 2 groups of patients. The only significant difference between the 2 groups was AJCC stage. Thirty\u2010five A\u20103 patients and 20 A\u20104 patients had overall survivals of 88% versus 80%, 82% versus 75%, and 66% versus 67.5% at 1, 2, and 3 years, respectively (<jats:italic>p<\/jats:italic> = .958). With regard to PEG dependence, no significant differences were seen between the 2 groups at 6, 12, or 18 months.<\/jats:p><\/jats:sec><jats:sec><jats:title><jats:italic>Conclusion.<\/jats:italic><\/jats:title><jats:p>PEG dependence was not significantly different between the 2 study groups. Type of altered fractionation scheme may not influence PEG dependence in patients treated with similar protocols. Future randomized studies are needed to confirm these findings. \u00a9 2009 Wiley Periodicals, Inc. 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