{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T01:02:50Z","timestamp":1776128570751,"version":"3.50.1"},"reference-count":16,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2009,4,9]],"date-time":"2009-04-09T00:00:00Z","timestamp":1239235200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2010,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title><jats:italic>Background.<\/jats:italic><\/jats:title><jats:p>Extranodal nasal\u2010type natural killer (NK)\/T\u2010cell lymphoma is a very uncommon disease process often mimicking refractory sinusitis. The diagnosis may be discovered after an extensive exclusion process. Careful immunohistochemical evaluation is crucial to differentiate NK\/T\u2010cell lymphoma from other malignancies.<\/jats:p><\/jats:sec><jats:sec><jats:title><jats:italic>Methods and Results.<\/jats:italic><\/jats:title><jats:p>We describe a 46\u2010year\u2010old white man presenting with a 4\u2010month history of refractory sinusitis and new onset visual field loss in his right eye, right facial tingling, and pain. Examination revealed right periorbital edema and scleritis, and necrotic appearing turbinates with purulence and fibrinous debris. CT\/MRI delineated extensive paranasal sinus involvement. Immunohistopathology demonstrated extranodal nasal\u2010type NK\/T\u2010cell lymphoma. Additional radiography revealed widespread involvement.<\/jats:p><\/jats:sec><jats:sec><jats:title><jats:italic>Conclusion.<\/jats:italic><\/jats:title><jats:p>Severe recalcitrant sinusitis with orbital involvement may be the initial presentation of NK\/T\u2010cell lymphoma. Ulcerative or necrotic lesions in the midline of the head and neck should raise concern for this disease. In addition to radiographic and laboratory testing, large biopsies should be taken for immunohistochemical analysis to achieve diagnosis and guide further management. \u00a9 2009 Wiley Periodicals, Inc. Head Neck, 2010<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.21068","type":"journal-article","created":{"date-parts":[[2009,4,9]],"date-time":"2009-04-09T17:13:57Z","timestamp":1239297237000},"page":"268-273","source":"Crossref","is-referenced-by-count":15,"title":["Extranodal nasal\u2010type natural killer\/T\u2010cell lymphoma masquerading as recalcitrant sinusitis"],"prefix":"10.1002","volume":"32","author":[{"given":"Young S.","family":"Paik","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin D.","family":"Liess","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Troy D.","family":"Scheidt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ellis A.","family":"Ingram","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"III","given":"Robert P.","family":"Zitsch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,4,9]]},"reference":[{"key":"e_1_2_5_2_2","first-page":"1391","article-title":"Quiz case 2: diagnosis natural killer (NK) cell\/peripheral T\u2010cell lymphoma","volume":"126","author":"Khariwala S","year":"2000","journal-title":"Arch Otolaryngol Head Neck Surg"},{"key":"e_1_2_5_3_2","first-page":"216","article-title":"Primary nasal natural killer cell lymphoma: long\u2010term outcome and relationship with the International Prognostic Index","volume":"103","author":"Chor\u2010Sang C","year":"2004","journal-title":"Neoplasia"},{"key":"e_1_2_5_4_2","first-page":"331","article-title":"Midline destructive lesions of the sinonasal tract: simplified terminology based on histopathologic criteria","volume":"21","author":"Borges A","year":"2000","journal-title":"Am J Neuroradiol"},{"key":"e_1_2_5_5_2","first-page":"204","volume-title":"Pathology and Genetics: Tumors of Haematopoietic and Lymphoid Tissues. 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