{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T01:35:08Z","timestamp":1791164108791,"version":"4.1.0"},"reference-count":24,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2009,4,9]],"date-time":"2009-04-09T00:00:00Z","timestamp":1239235200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2009,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title><jats:italic>Background.<\/jats:italic><\/jats:title><jats:p>To analyze clinical features and to discuss the modality of investigation and treatment of a series of mucosa\u2010associated lymphoid tissue (MALT) lymphomas. To investigate the prevalence of aberrant promoter methylation, responsible for gene inactivation, in a selected panel of genes potentially involved in the pathogenesis of B\u2010cell malignancies as O6\u2010methylguanine\u2010DNA methyltransferase (<jats:italic>MGMT<\/jats:italic>), p73, death\u2010associated protein kinase (<jats:italic>DAP\u2010k<\/jats:italic>).<\/jats:p><\/jats:sec><jats:sec><jats:title><jats:italic>Methods.<\/jats:italic><\/jats:title><jats:p>Nine patients with primary MALT lymphoma of the salivary glands were retrospectively reviewed. <jats:italic>MGMT, p73, DAP\u2010k<\/jats:italic> apoptotic pathways were tested.<\/jats:p><\/jats:sec><jats:sec><jats:title><jats:italic>Results.<\/jats:italic><\/jats:title><jats:p>Methylation of DAP\u2010k was common (5\/8; 63%). Histological examination ensured diagnostic confirmation, whereas fine\u2010needle aspiration cytology was not definitively diagnostic.<\/jats:p><\/jats:sec><jats:sec><jats:title><jats:italic>Conclusion.<\/jats:italic><\/jats:title><jats:p>Histological assessment is the gold standard in the diagnosis of salivary gland lesions. Parotidectomy represents a safe and reliable diagnostic tool leading to a definite diagnosis of MALT lymphomas in all cases and curative without other treatment in early\u2010stage MALT lymphoma. \u00a9 2009 Wiley Periodicals, Inc. Head Neck, 2009<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.21087","type":"journal-article","created":{"date-parts":[[2009,4,9]],"date-time":"2009-04-09T17:13:04Z","timestamp":1239297184000},"page":"1181-1187","source":"Crossref","is-referenced-by-count":18,"title":["Clinical and molecular features of mucosa\u2010associated lymphoid tissue (MALT) lymphomas of salivary glands"],"prefix":"10.1002","volume":"31","author":[{"given":"Andrea","family":"Toso","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Aluffi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Capello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annarita","family":"Conconi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianluca","family":"Gaidano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Pia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,4,9]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19831015)52:8<1410::AID-CNCR2820520813>3.0.CO;2-3"},{"key":"e_1_2_5_3_2","first-page":"157","volume-title":"Pathology and genetics: tumours of haematopoietic and lymphoid tissues (World Health Organization Classification of Tumours)","author":"Isaacson PG","year":"2001"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V89.11.3909"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.beha.2004.08.003"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19860801)58:3<699::AID-CNCR2820580317>3.0.CO;2-E"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation-2001.1.241"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000421-198212000-00014"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.18.9821"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/94.1.26"},{"key":"e_1_2_5_11_2","doi-asserted-by":"crossref","first-page":"4347","DOI":"10.1182\/blood.V93.12.4347","article-title":"Hypermethylation of the DAP\u2010kinase CpG island is a common alteration in Bcell malignancies","volume":"93","author":"Katzenellenbogen RA","year":"1999","journal-title":"Blood"},{"key":"e_1_2_5_12_2","first-page":"3352","article-title":"Transcriptional silencing of the p73 gene in acute lymphoblastic leukemia and Burkitt's lymphoma is associated with 5\u2032 CpG island methylation","volume":"59","author":"Corn PG","year":"1999","journal-title":"Cancer Res"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2004.04993.x"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2404517"},{"key":"e_1_2_5_15_2","first-page":"154","article-title":"Aberrant promoter methylation of multiple genes throughout the clinico\u2010pathologic spectrum of B\u2010cell neoplasia","volume":"89","author":"Rossi D","year":"2004","journal-title":"Haematologica"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2007.03.043"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1080\/10428190701573224"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/38298"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0339(20000301)22:3<139::AID-DC2>3.0.CO;2-A"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/dc.20563"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1080\/00016480410017495"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-04-2282"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.11317"},{"key":"e_1_2_5_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.1992.tb01019.x"},{"key":"e_1_2_5_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(88)80259-4"}],"container-title":["Head &amp; 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