{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T00:39:55Z","timestamp":1778891995390,"version":"3.51.4"},"reference-count":23,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2009,4,29]],"date-time":"2009-04-29T00:00:00Z","timestamp":1240963200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2009,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background.<\/jats:title><jats:p>Treatment of base of tongue (BOT) squamous cell carcinoma (SCC) has traditionally been associated with poor prognosis and significant morbidity. We report a program consisting of concurrent chemoradiation followed by brachytherapy for these patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods.<\/jats:title><jats:p>We reviewed all patients in our institution with previously untreated BOT SCC (1996\u20132004) who received this treatment program.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results.<\/jats:title><jats:p>In 88 patients (median age, 60.2 years; 37 T1\/T2; 51 T3\/T4), cervical lymph node metastases were present in 71 patients (80.7%). Six patients had residual\/subsequent cervical metastases requiring 7 neck dissections. Local recurrence occurred in 16 patients (18.2%) and distant metastases occurred in 9 patients (10.2%). Median follow\u2010up time was 3.1 years (range, 0.5\u20137.8 years). Three\u2010year overall survival was 80.9% (95% CI: 69.6% to 88.3%). Locoregional control rate was 79.9% and disease\u2010specific survival was 69.5% at 3 years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions.<\/jats:title><jats:p>Concurrent chemoradiotherapy followed with brachytherapy is a safe and effective method of treatment of SCC of the BOT. \u00a9 2009 Wiley Periodicals, Inc. Head Neck, 2009<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.21111","type":"journal-article","created":{"date-parts":[[2009,4,29]],"date-time":"2009-04-29T16:22:09Z","timestamp":1241022129000},"page":"1431-1438","source":"Crossref","is-referenced-by-count":18,"title":["Management of squamous cell carcinoma of the base of tongue with chemoradiation and brachytherapy"],"prefix":"10.1002","volume":"31","author":[{"given":"Elmer R.","family":"Cano","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen Y.","family":"Lai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatma","family":"Caylakli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonas T.","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert L.","family":"Ferris","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo L.","family":"Carrau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carl H.","family":"Snyderman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William E.","family":"Gooding","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"Alfred A.","family":"Simenthal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eugene N.","family":"Myers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,4,29]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/hed.20064"},{"key":"e_1_2_5_3_2","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/978-1-4757-3656-4","volume-title":"Cancer staging manual","author":"Greene FLPD","year":"2002"},{"key":"e_1_2_5_4_2","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/j.2517-6161.1972.tb00899.x","article-title":"Regression models and life tables","volume":"34","author":"Cox D","year":"1972","journal-title":"J R Stat Soc B"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1053-4296(98)80021-0"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa031317"},{"key":"e_1_2_5_7_2","first-page":"297","article-title":"Teletherapy versus teletherapy and \u201cboost\u201d brachytherapy in the treatment of base of tongue tumors: 5\u2010year results","volume":"48","author":"Takacsi Nagy Z","year":"2004","journal-title":"Magy Onkol"},{"key":"e_1_2_5_8_2","first-page":"76","article-title":"The importance of interstitial radiotherapy in the treatment of the base of tongue tumors: a retrospective analysis","volume":"48","author":"Takacsi\u2010Nagy Z","year":"2001","journal-title":"Neoplasma"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(03)01370-1"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00179299"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brachy.2004.02.001"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/hed.20171"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(88)90003-X"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000421-200210000-00013"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2007.04.083"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2008.02.061"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(03)00597-2"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1177\/030089160208800211"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.129.9.983"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/hed.20528"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2005.03.066"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1097\/MLG.0b013e318149e6bc"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.184.1.1609090"},{"key":"e_1_2_5_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.22648"}],"container-title":["Head &amp; Neck"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhed.21111","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.21111","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,9]],"date-time":"2025-02-09T06:23:09Z","timestamp":1739082189000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hed.21111"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,4,29]]},"references-count":23,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2009,11]]}},"alternative-id":["10.1002\/hed.21111"],"URL":"https:\/\/doi.org\/10.1002\/hed.21111","archive":["Portico"],"relation":{},"ISSN":["1043-3074","1097-0347"],"issn-type":[{"value":"1043-3074","type":"print"},{"value":"1097-0347","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,4,29]]}}}