{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T21:14:22Z","timestamp":1760217262436},"reference-count":21,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2009,5,13]],"date-time":"2009-05-13T00:00:00Z","timestamp":1242172800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2010,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background.<\/jats:title><jats:p>The authors report on leiomyosarcoma after previously treated squamous cell carcinoma (SCC) at the glottis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods.<\/jats:title><jats:p>Primary tumor and relapses were investigated morphologically, immunohistochemically, and with molecular methods.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results.<\/jats:title><jats:p>The SCC was typical, but few cells showed a spindle\u2010shaped pattern. The relapse tumor was a spindle\u2010shaped and epitheloid tumor with the morphological and immunohistochemical appearance of leiomyosarcoma (sm\u2010actin+, desmin+, caldesmon+, vimentin+, keratin\u2212).<\/jats:p><jats:p>The comparative genomic hybridization (CGH) revealed some gains and losses in the leiomyosarcoma. Because of altered material, the investigation failed in the primary. A fluorescence in situ hybridization (5p) focally detected 3 chromosmomal copies, corresponding to gains on 5p in CGH of leiomyosarcoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion.<\/jats:title><jats:p>Leiomyosarcoma after SCC is very uncommon. A connection between both seems likely in this case. Transdifferentiation, also seen in other tumors or carcinosarcomas, could be based on aberrant differentiation of a pluripotent stem cell. \u00a9 2009 Wiley Periodicals, Inc. Head Neck, 2010<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.21127","type":"journal-article","created":{"date-parts":[[2009,5,13]],"date-time":"2009-05-13T19:35:01Z","timestamp":1242243301000},"page":"679-683","source":"Crossref","is-referenced-by-count":4,"title":["Leiomyosarcoma of the larynx as a local relapse of squamous cell carcinoma\u2014Report of an unusual case"],"prefix":"10.1002","volume":"32","author":[{"given":"Hans\u2010Ullrich","family":"V\u00f6lker","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Zettl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eugenia","family":"Haralambieva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernd","family":"Blume","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rudolf","family":"Hagen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans\u2010Konrad","family":"M\u00fcller\u2010Hermelink","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias","family":"Scheich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,4,8]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1177\/000348949910800711"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-006-0092-0"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2004.11.007"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0347(199809)20:6<563::AID-HED12>3.0.CO;2-L"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)64536-1"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-008-0583-z"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.2196"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2007.02646.x"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc0707079"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1442-2050.2001.00194.x"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1067\/moe.2001.111093"},{"key":"e_1_2_5_13_2","first-page":"560","article-title":"Concurrent leiomyosarcoma and squamous carcinoma of the esophagus","volume":"51","author":"Ovens JM","year":"1951","journal-title":"AMA Arch Pathol"},{"key":"e_1_2_5_14_2","first-page":"1254","article-title":"Concurrent leiomyosarcoma and squamous cell carcinoma of esophagus","volume":"65","author":"Rella AJ","year":"1965","journal-title":"N Y State J Med"},{"key":"e_1_2_5_15_2","first-page":"740","article-title":"Leiomyosarcoma of the esophagus. Report of two cases, one with associated squamous cell carcinoma","volume":"75","author":"Gaede JT","year":"1978","journal-title":"J Thorac Cardiovasc Surg"},{"key":"e_1_2_5_16_2","first-page":"1489","article-title":"A case of penile tumor: combination of leiomyosarcoma and squamous cell carcinoma","volume":"33","author":"Koizumi H","year":"1987","journal-title":"Hinyokika Kiyo"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-4608(99)00105-3"},{"key":"e_1_2_5_18_2","first-page":"407","article-title":"Significant involvement of chromosome 13q deletions in progression of larynx cancer, detected by comparative genomic hybridization","volume":"46","author":"Schlade\u2010Bartusiak K","year":"2005","journal-title":"J Appl Genet"},{"key":"e_1_2_5_19_2","first-page":"191","article-title":"Chromosomal changes in relation to clinical outcome in larynx and pharynx squamous cell carcinoma","volume":"27","author":"Hermsen M","year":"2005","journal-title":"Cell Oncol"},{"key":"e_1_2_5_20_2","first-page":"BR279","article-title":"Chromosome alterations reflect clonal evolution in squamous cell carcinoma of the larynx","volume":"8","author":"Kujawski M","year":"2002","journal-title":"Med Sci Monit"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-4608(02)00545-9"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.10062"}],"container-title":["Head &amp; Neck"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhed.21127","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.21127","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T00:28:54Z","timestamp":1696897734000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hed.21127"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,4,8]]},"references-count":21,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2010,5]]}},"alternative-id":["10.1002\/hed.21127"],"URL":"https:\/\/doi.org\/10.1002\/hed.21127","archive":["Portico"],"relation":{},"ISSN":["1043-3074","1097-0347"],"issn-type":[{"value":"1043-3074","type":"print"},{"value":"1097-0347","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,4,8]]}}}