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Analysis of results may be a step to improve the efficacy of this therapy for early glottic cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods.<\/jats:title><jats:p>In all, 81 patients who underwent surgery with CO<jats:sub>2<\/jats:sub> laser for Tis and T1, AC0 to AC2 glottic carcinoma were followed up to 55 months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results.<\/jats:title><jats:p>The incidence of recurrence increased significantly with T and AC classifications. The disease\u2010free interval decreased with increasing T and AC classifications and with increasing severity of histology, but only the AC classification appeared significant. Recurrences occurred in 5 of 35 patients upon type I and type II cordectomy, in 16 of 24 patients upon type V cordectomy, and never upon type III and IV cordectomy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions.<\/jats:title><jats:p>Type I to type IV cordectomy, when indicated, can achieve radical treatment of most T1 glottic cancer. Type V cordectomy requires that any suspicion of cartilage invasion, even microscopic, be excluded. \u00a9 2009 Wiley Periodicals, Inc. 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