{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T21:23:56Z","timestamp":1771881836097,"version":"3.50.1"},"reference-count":20,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2010,1,20]],"date-time":"2010-01-20T00:00:00Z","timestamp":1263945600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2010,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title><jats:italic>Background.<\/jats:italic><\/jats:title><jats:p>Expression of placenta growth factor (PlGF) is found to correlate with the progression and prognosis of several human cancers.<\/jats:p><\/jats:sec><jats:sec><jats:title><jats:italic>Methods.<\/jats:italic><\/jats:title><jats:p>This study used an immunohistochemical technique to examine the expression of PlGF in 100 specimens of oral squamous cell carcinoma (OSCC).<\/jats:p><\/jats:sec><jats:sec><jats:title><jats:italic>Results.<\/jats:italic><\/jats:title><jats:p>We found that the higher mean PlGF labeling index was significantly associated with OSCCs with positive lymph node metastasis (<jats:italic>p<\/jats:italic> = .014) or with more advanced clinical stages (<jats:italic>p<\/jats:italic> = .016). Positive lymph node metastasis (<jats:italic>p<\/jats:italic> = .008) and PlGF labeling index &gt;40% (<jats:italic>p<\/jats:italic> = .010) were identified as independent unfavorable prognosis factors by multivariate analyses with Cox regression model. Moreover, a Kaplan\u2013Meier curve showed that OSCC patients with a PlGF labeling index &gt;40% had a significantly poorer cumulative survival than those with a PlGF labeling index \u226440% (log\u2010rank test, <jats:italic>p<\/jats:italic> = .003).<\/jats:p><\/jats:sec><jats:sec><jats:title><jats:italic>Conclusions.<\/jats:italic><\/jats:title><jats:p>The PlGF labeling index can predict the progression and prognosis of OSCCs in Taiwan. \u00a9 2010 Wiley Periodicals, Inc. Head Neck, 2010<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.21335","type":"journal-article","created":{"date-parts":[[2010,1,20]],"date-time":"2010-01-20T15:44:28Z","timestamp":1264002268000},"page":"1363-1369","source":"Crossref","is-referenced-by-count":19,"title":["Expression of placenta growth factor: An independent factor for prediction of progression and prognosis of oral cancer"],"prefix":"10.1002","volume":"32","author":[{"given":"Shih\u2010Jung","family":"Cheng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jang\u2010Jaer","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sang\u2010Heng","family":"Kok","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chia\u2010Hsuan","family":"Chou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao\u2010Hueng","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meng","family":"Ling Chiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hsin\u2010Ming","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark Yen\u2010Ping","family":"Kuo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun\u2010Pin","family":"Chiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,1,20]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2005.07.038"},{"key":"e_1_2_5_3_2","volume-title":"Cancer registry annual report in Taiwan area, 2006","year":"2007"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2524"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9896(199909)189:1<66::AID-PATH390>3.0.CO;2-X"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1006198422718"},{"key":"e_1_2_5_7_2","first-page":"4233","article-title":"Markedly increased amounts of messenger RNAs for vascular endothelial growth factor and placenta growth factor in renal cell carcinoma associated with angiogenesis","volume":"54","author":"Takahashi A","year":"1994","journal-title":"Cancer Res"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7819-3-68"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2005.07.022"},{"key":"e_1_2_5_10_2","first-page":"508","article-title":"Placenta growth factor is abundantly expressed in human cervical squamous cell carcinoma","volume":"18","author":"Kodama J","year":"1997","journal-title":"Eur J Gynaecol Oncol"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2006.10.005"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2004.05.020"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2004.050831"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2006.051041"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2000.00199.x"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.2005.00505.x"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/35025220"},{"key":"e_1_2_5_18_2","doi-asserted-by":"crossref","first-page":"25646","DOI":"10.1016\/S0021-9258(18)47298-5","article-title":"Placenta growth factor: Potentiation of vascular endothelial growth factor bioactivity, in vitro and in vivo, and high affinity binding to Flt\u20101 but not to Flk\u20101\/KDR","volume":"269","author":"Park JE","year":"1994","journal-title":"J Biol Chem"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-11-3423"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.21831"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-06-0461"}],"container-title":["Head &amp; 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