{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T10:26:48Z","timestamp":1761128808141},"reference-count":12,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2010,2,9]],"date-time":"2010-02-09T00:00:00Z","timestamp":1265673600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2011,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background.<\/jats:title><jats:p>Tumor\u2010induced osteomalacia (TIO) is a rare clinical entity in which secondary osteomalacia is induced by tumor\u2010related products. Fibroblast growth factor 23 (FGF\u201023) mRNA is overexpressed in the tumor tissue, leading to impaired reabsorption of phosphorus in the renal tubules and hypophosphatemia. Curative treatment is considered to be total resection of the tumor.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results.<\/jats:title><jats:p>A 53\u2010year\u2010old woman had experienced systemic bone pain and muscle weakness for several years. She had refractory hypophosphatemia and marked elevation of serum FGF\u201023 level. Whole body imaging eventually revealed a hypervascular mass in the right temporal bone, leading to a diagnosis of TIO. She underwent skull\u2010base surgery after embolization of the tumor. After the en bloc resection, FGF\u201023 became undetectable, phosphate reabsorption normalized, and all symptoms resolved.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions.<\/jats:title><jats:p>We discuss the clinical features and treatment options for this rare disease. \u00a9 2010 Wiley Periodicals, Inc. Head Neck, 2011<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.21355","type":"journal-article","created":{"date-parts":[[2010,2,9]],"date-time":"2010-02-09T16:39:09Z","timestamp":1265733549000},"page":"1072-1075","source":"Crossref","is-referenced-by-count":11,"title":["Tumor\u2010induced osteomalacia originating from the temporal bone: A case report"],"prefix":"10.1002","volume":"33","author":[{"given":"Kenya","family":"Kobayashi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazunari","family":"Nakao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kensuke","family":"Kawai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ken","family":"Ito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seiji","family":"Hukumoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahiro","family":"Asakage","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Oota","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryo","family":"Motoi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,6,14]]},"reference":[{"key":"e_1_2_5_2_2","first-page":"33","article-title":"Osteomalacia with Looser's nodes (Milkman's syndrome) due to a raised resistance to vitamin D acquired about the age of 15 years","volume":"16","author":"McCance RA","year":"1947","journal-title":"QJM"},{"key":"e_1_2_5_3_2","first-page":"554","article-title":"Rachitis infolge knochentumors (Rickets caused by bone tumors)","volume":"14","author":"Prader AV","year":"1959","journal-title":"Helv Paediatr Acta"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.86.2.7408"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2005.03.086"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(84)90112-8"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100140551"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2004-0406"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19850415)55:8<1691::AID-CNCR2820550814>3.0.CO;2-S"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s100240050008"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/lary.1983.93.10.1328"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa010839"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.rhu.0000101906.15276.ed"}],"container-title":["Head &amp; Neck"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhed.21355","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.21355","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T16:00:33Z","timestamp":1700582433000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hed.21355"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,6,14]]},"references-count":12,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2011,7]]}},"alternative-id":["10.1002\/hed.21355"],"URL":"https:\/\/doi.org\/10.1002\/hed.21355","archive":["Portico"],"relation":{},"ISSN":["1043-3074","1097-0347"],"issn-type":[{"value":"1043-3074","type":"print"},{"value":"1097-0347","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,6,14]]}}}