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Indications included nodal involvement, T3\/T4 tumors, positive margins, those patients refusing surgery, or were medically inoperable. The most common regimen was paclitaxel (100 mg\/m2 on day 1), infusional 5\u2010fluorouracil (600 mg\/m2\/day \u00d7 5 days), hydroxyurea (500 mg prescribed orally [PO] 2 \u00d7 daily [BID]), and 1.5 Gy twice daily irradiation followed by a 9\u2010day break without treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Median follow\u2010up was 51 months. The median dose to gross tumor was 72.5 Gy (range, 40\u201375.5 Gy). Five\u2010year locoregional progression\u2010free survival, overall survival, and disease\u2010free survival was 87.0%, 58.2%, and 46.0%, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Concurrent chemoradiotherapy results in promising locoregional control for base of tongue cancer. As distant relapse was common, further investigation of systemic therapy with novel agents may be warranted. \u00a9 2010 Wiley Periodicals, Inc. 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