{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T15:04:25Z","timestamp":1793804665681,"version":"4.6.1"},"reference-count":33,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2010,3,22]],"date-time":"2010-03-22T00:00:00Z","timestamp":1269216000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2011,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background.<\/jats:title>\n                    <jats:p>The management of bisphosphonate\u2010related osteonecrosis of the jaws (BRONJ) is challenging and controversial. At present, there is no established medication treatment for the disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods.<\/jats:title>\n                    <jats:p>A 78\u2010year\u2010old osteoporotic woman with osteonecrosis of the mandible related to alendronate therapy was referred for treatment. The disease was unresponsive to conservative therapy, including antibacterial mouth rinse, antibiotics, and minor surgical debridement. Teriparatide, a human recombinant pararthyroid hormone peptide 1\u201334, was then used for treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results.<\/jats:title>\n                    <jats:p>The oral mucosa completely regrew, and pain subsided 4 weeks after the initiation of teriparatide administration. Progressive bone regeneration was found during and after the 6\u2010month period of teriparatide therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion.<\/jats:title>\n                    <jats:p>Our case demonstrated that teriparatide can be an important adjuvant in the management of advanced BRONJ and should be considered prior to major resection with reconstruction. Its true value in the treatment of BRONJ for noncancer patients with osteoporosis warrants future studies. \u00a9 2010 Wiley Periodicals, Inc. Head Neck, 2010<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hed.21380","type":"journal-article","created":{"date-parts":[[2010,3,22]],"date-time":"2010-03-22T16:30:08Z","timestamp":1269275408000},"page":"1366-1371","source":"Crossref","is-referenced-by-count":71,"title":["Successful treatment of advanced bisphosphonate\u2010related osteonecrosis of the mandible with adjunctive teriparatide therapy"],"prefix":"10.1002","volume":"33","author":[{"given":"Jang\u2010Jaer","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shih\u2010Jung","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiiang\u2010Huei","family":"Jeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun\u2010Pin","family":"Chiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hon\u2010Ping","family":"Lau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang\u2010Heng","family":"Kok","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,8,11]]},"reference":[{"key":"e_1_2_4_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-007-0540-8"},{"key":"e_1_2_4_3_2","doi-asserted-by":"publisher","DOI":"10.1177\/154405910708601102"},{"key":"e_1_2_4_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-77991-6_5"},{"key":"e_1_2_4_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/hon.819"},{"key":"e_1_2_4_6_2","first-page":"6538","article-title":"Bisphosphonates inhibit angiogenesis in vitro and testosterone\u2010stimulated vascular regrowth in the ventral prostate in castrated rats","volume":"62","author":"Fournier P","year":"2002","journal-title":"Cancer Res"},{"key":"e_1_2_4_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0278-2391(03)00720-1"},{"key":"e_1_2_4_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2007.08.008"},{"key":"e_1_2_4_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2008.01.003"},{"key":"e_1_2_4_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2009.01.009"},{"key":"e_1_2_4_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2007.08.003"},{"key":"e_1_2_4_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21130"},{"key":"e_1_2_4_13_2","doi-asserted-by":"publisher","DOI":"10.1532\/IJH97.06110"},{"key":"e_1_2_4_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2007.03.019"},{"key":"e_1_2_4_15_2","doi-asserted-by":"publisher","DOI":"10.1159\/000097876"},{"key":"e_1_2_4_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2009.03.005"},{"key":"e_1_2_4_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2006.07.012"},{"key":"e_1_2_4_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2008.05.002"},{"key":"e_1_2_4_19_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000187398.51857.3c"},{"key":"e_1_2_4_20_2","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.2001.16.10.1846"},{"key":"e_1_2_4_21_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200105103441904"},{"key":"e_1_2_4_22_2","doi-asserted-by":"publisher","DOI":"10.1210\/er.2004-0006"},{"key":"e_1_2_4_23_2","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.1999.14.6.960"},{"key":"e_1_2_4_24_2","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.G.01443"},{"key":"e_1_2_4_25_2","doi-asserted-by":"publisher","DOI":"10.1177\/00220345000790061301"},{"key":"e_1_2_4_26_2","doi-asserted-by":"publisher","DOI":"10.1177\/00220345970760080901"},{"key":"e_1_2_4_27_2","first-page":"407","article-title":"Effects of platelet\u2010derived growth factor, vitamin D and parathyroid hormone on osteoblasts derived from cancer patients on chronic bisphosphonate therapy","volume":"23","author":"Rao MV","year":"2009","journal-title":"Int J Mol Med"},{"key":"e_1_2_4_28_2","first-page":"185","volume-title":"The parathyroids","author":"Murray TM","year":"1994"},{"key":"e_1_2_4_29_2","doi-asserted-by":"publisher","DOI":"10.1210\/en.2002-221061"},{"key":"e_1_2_4_30_2","doi-asserted-by":"publisher","DOI":"10.1359\/JBMR.040126"},{"key":"e_1_2_4_31_2","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.090527"},{"key":"e_1_2_4_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2006.10.076"},{"key":"e_1_2_4_33_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00223-009-9218-x"},{"key":"e_1_2_4_34_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11154-006-9007-z"}],"container-title":["Head &amp; 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