{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T15:09:20Z","timestamp":1790262560859,"version":"4.1.0"},"reference-count":39,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2010,4,27]],"date-time":"2010-04-27T00:00:00Z","timestamp":1272326400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2010,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Hepatocyte growth factor (HGF) can promote proliferation, invasion, and angiogenesis in various tumor cells. However, the prognosis according to expression of HGF\/c\u2010Met has not been reported in patients with squamous cell carcinoma of the oral tongue (SCCOT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Tumors from 61 patients with SCCOT were evaluated for the expression of HGF and c\u2010Met by immunohistochemistry. For Western blot, we used fresh normal and cancer tissues from 3 patients with SCCOT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The positive rates of HGF and c\u2010Met immunostaining in SCCOT were 57.3% and 54.1%, respectively. The c\u2010Met staining was significantly correlated with lymph node metastasis (<jats:italic>p<\/jats:italic> = .005), tumor classification (<jats:italic>p<\/jats:italic> = .004), and recurrence (<jats:italic>p<\/jats:italic> = .018). Survival was significantly affected in patients with positive c\u2010Met expression (<jats:italic>p<\/jats:italic> = .003). HGF and c\u2010Met were strongly expressed in cancer tissues on Western blot.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The c\u2010Met expression may play an important role in the progression and the survival outcome of patients with SCCOT. \u00a9 2010 Wiley Periodicals, Inc. Head Neck, 2010<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.21383","type":"journal-article","created":{"date-parts":[[2010,4,28]],"date-time":"2010-04-28T20:14:56Z","timestamp":1272485696000},"page":"1655-1664","source":"Crossref","is-referenced-by-count":45,"title":["c\u2010Met expression as an indicator of survival outcome in patients with oral tongue carcinoma"],"prefix":"10.1002","volume":"32","author":[{"given":"Chul\u2010Ho","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoon Woo","family":"Koh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae Ho","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae Wook","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin 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