{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T15:45:33Z","timestamp":1768319133751,"version":"3.49.0"},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2011,3,21]],"date-time":"2011-03-21T00:00:00Z","timestamp":1300665600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2011,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The purpose of this study was to identify the prognostic factors affecting the outcome in patients with mucoepidermoid carcinoma (MEC) of the parotid gland.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 113 patients with MEC who were treated between 1993 and 2002 were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At median follow\u2010up of 49 months (range, 1\u2013143 months), disease\u2010free survival (DFS) at 5 and 10 years was 84.6 and 84.6%, 80.7% and 67.3%, and 52.5% and 35.0% for low\u2010grade, intermediate\u2010grade, and high\u2010grade tumors, respectively. Five\u2010year and 10\u2010year overall survival was 96.8% for low\u2010grade tumors; 94.1% and 82.4%, respectively, for intermediate\u2010grade tumors; and 73.3% for high\u2010grade tumors. High\u2010grade tumors and lymph node cancer\u2010positive neck tumors strongly predicted poor locoregional control and DFS, while close or positive cut margins showed a trend toward poorer outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Histologic grade is the most important factor affecting outcome in parotid MEC. Adjuvant radiotherapy is recommended for high\u2010grade tumors and should be tailored according to the expected risk of recurrence for low\u2010grade and intermediate\u2010grade tumors. \u00a9 2010 Wiley Periodicals, Inc. 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