{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T12:46:35Z","timestamp":1792673195234,"version":"4.5.0"},"reference-count":21,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2010,10,19]],"date-time":"2010-10-19T00:00:00Z","timestamp":1287446400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2011,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The aim of the present analysis was to retrospectively evaluate outcomes in patients with cutaneous angiosarcoma of the face\/scalp treated curatively with surgery, radiation therapy (RT), or a combination of surgery and RT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In all, 70 patients with nonmetastatic angiosarcoma underwent surgery, RT, or combined\u2010modality therapy. Of these, 20 patients (29%) were treated with surgery alone, 27 patients (39%) with RT alone, and 23 patients (33%) with combined\u2010modality therapy; 44 patients received chemotherapy, either neoadjuvantly or adjuvantly or both.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Median follow\u2010up was 2.1 years. The overall survival (OS) rate was 43% at 5 years, and disease\u2010specific survival (DSS) was 46% at 5 years. Tumor size &gt; 5 cm and satellitosis were prognostic for inferior OS and DSS. Combined\u2010modality therapy (vs surgery alone or RT alone) was associated with improved OS, DSS, and local control.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Primary local therapy with combined\u2010modality therapy was associated with improved local control, OS, and DSS for patients with angiosarcoma of the face\/scalp. \u00a9 2010 Wiley Periodicals, Inc. Head Neck, 2011<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.21513","type":"journal-article","created":{"date-parts":[[2010,10,19]],"date-time":"2010-10-19T17:51:41Z","timestamp":1287510701000},"page":"661-667","source":"Crossref","is-referenced-by-count":158,"title":["Outcomes after definitive treatment for cutaneous angiosarcoma of the face and scalp"],"prefix":"10.1002","volume":"33","author":[{"given":"B. Ashleigh","family":"Guadagnolo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunar K.","family":"Zagars","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dejka","family":"Araujo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinod","family":"Ravi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas D.","family":"Shellenberger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erich M.","family":"Sturgis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,10,19]]},"reference":[{"key":"e_1_2_5_2_2","first-page":"703","volume-title":"Enzinger and Weiss's soft tissue tumors","author":"Weiss SW","year":"2008"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19811015)48:8<1907::AID-CNCR2820480832>3.0.CO;2-T"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.11667"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/SAP.0b013e31816b31f8"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19870301)59:5<1046::AID-CNCR2820590533>3.0.CO;2-6"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(01)02753-5"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2003.10.671"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19960601)77:11<2400::AID-CNCR32>3.0.CO;2-Z"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2008.07.022"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/hed.10276"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1155\/2000\/575781"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(05)80097-2"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197909)44:3<1106::AID-CNCR2820440345>3.0.CO;2-C"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2004.08.008"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19991115)86:10<2034::AID-CNCR21>3.0.CO;2-P"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19950715)76:2<319::AID-CNCR2820760224>3.0.CO;2-8"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21979"},{"key":"e_1_2_5_19_2","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/j.2517-6161.1972.tb00899.x","article-title":"Regression models and life tables","volume":"34","author":"Cox D","year":"1972","journal-title":"J R Stat Soc B"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.328.7441.702"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11864-007-0042-0"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21140"}],"container-title":["Head &amp; Neck"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhed.21513","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.21513","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,26]],"date-time":"2025-02-26T21:59:09Z","timestamp":1740607149000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hed.21513"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,10,19]]},"references-count":21,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2011,5]]}},"alternative-id":["10.1002\/hed.21513"],"URL":"https:\/\/doi.org\/10.1002\/hed.21513","archive":["Portico"],"relation":{},"ISSN":["1043-3074","1097-0347"],"issn-type":[{"value":"1043-3074","type":"print"},{"value":"1097-0347","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,10,19]]}}}