{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T23:41:11Z","timestamp":1788392471943,"version":"build-2803163510"},"reference-count":30,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2010,10,21]],"date-time":"2010-10-21T00:00:00Z","timestamp":1287619200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2011,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The optimal treatment for base of tongue cancer remains unclear, especially in advanced stages.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively review 84 previously untreated patients that underwent a transhyoid resection of a base of tongue carcinoma. Sixty\u2010four patients (76%) underwent postoperative radiotherapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Five patients had stage II disease, 6 had stage III, 58 had stage IVA, and 15 had stage IVB. The overall recurrence rate was 68%. Five\u2010year disease\u2010specific survival rates by stage were 100%, 67%, 27%, and 8% for stage II to IVB, respectively (<jats:italic>p<\/jats:italic> = .0007). Multivariate analysis showed that the presence of lymph node metastases was an independent predictor of reduced disease\u2010specific survival rates (<jats:italic>p<\/jats:italic> = .02). All patients maintained an intelligible voice, and oral alimentation was successfully recovered in 97.5% of them.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The transhyoid approach allowed adequate resection of base of tongue cancers with low morbidity and acceptable functional results, but the oncologic outcomes in advanced stages are poor. Head Neck, 2011<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.21569","type":"journal-article","created":{"date-parts":[[2010,10,21]],"date-time":"2010-10-21T18:28:27Z","timestamp":1287685707000},"page":"1079-1084","source":"Crossref","is-referenced-by-count":10,"title":["Oncologic and functional results after transhyoid surgical approach for cancer of the base of tongue"],"prefix":"10.1002","volume":"33","author":[{"given":"Juan P.","family":"Rodrigo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Pablo","family":"D\u00edaz\u2010Molina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla","family":"Moreno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Su\u00e1rez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,10,21]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1177\/000348940711600203"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6603044"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-009-1109-2"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-003-0694-8"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000244159.64179.f0"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2003.08.004"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-009-1089-2"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.coc.0000189680.60262.eb"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/hed.20171"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/hed.20694"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/hed.20947"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/jso.2930080510"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1177\/000348949009900410"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-199105000-00020"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1991.01870190069014"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-199206000-00008"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1177\/019459989411100112"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-199608000-00006"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200011000-00005"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.128.9.1067"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200307000-00026"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/hed.1092"},{"key":"e_1_2_5_24_2","doi-asserted-by":"publisher","DOI":"10.1053\/ejso.2000.0946"},{"key":"e_1_2_5_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brachy.2004.02.001"},{"key":"e_1_2_5_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/hed.20064"},{"key":"e_1_2_5_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.otc.2004.10.016"},{"key":"e_1_2_5_28_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.10567"},{"key":"e_1_2_5_29_2","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21269"},{"key":"e_1_2_5_30_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.10960"},{"key":"e_1_2_5_31_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.23458"}],"container-title":["Head &amp; Neck"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhed.21569","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.21569","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T13:52:17Z","timestamp":1700574737000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hed.21569"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,10,21]]},"references-count":30,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2011,8]]}},"alternative-id":["10.1002\/hed.21569"],"URL":"https:\/\/doi.org\/10.1002\/hed.21569","archive":["Portico"],"relation":{},"ISSN":["1043-3074","1097-0347"],"issn-type":[{"value":"1043-3074","type":"print"},{"value":"1097-0347","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,10,21]]}}}