{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T22:25:50Z","timestamp":1787610350496,"version":"build-2736575974"},"reference-count":22,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2010,11,10]],"date-time":"2010-11-10T00:00:00Z","timestamp":1289347200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2011,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background.<\/jats:title><jats:p>Salivary gland carcinomas are rare malignancies, particularly in young individuals in whom only scanty data are available from published studies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods.<\/jats:title><jats:p>We searched the SEER database (1973\u20132006) for patients with a reported diagnosis of salivary gland carcinoma; children\/adolescents (&lt;20 years old) were compared with adults.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results.<\/jats:title><jats:p>We identified 263 children\/adolescents (58% girls) and 12,571 adults (43% women). The most common histology was mucoepidermoid carcinoma in both groups, but the percentages of other histologies were different. Children\/adolescents had more favorable features with most tumors being localized, with no extension to adjacent tissues or lymphatic spread (76% vs 50% in adults, <jats:italic>p<\/jats:italic> &lt; .001). Also most tumors were well differentiated or moderately differentiated (88% vs 49% in adults, <jats:italic>p<\/jats:italic> &lt; .001). The 5\u2010year overall survival for children\/adolescents was 95% \u00b1 1.5%, compared with 59% \u00b1 0.5% for adults (<jats:italic>p<\/jats:italic> &lt; .001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion.<\/jats:title><jats:p>When compared with adults, salivary gland carcinomas in children\/adolescents are less advanced, and have more favorable features and better outcome. \u00a9 2010 Wiley Periodicals, Inc. Head Neck, 2010<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.21629","type":"journal-article","created":{"date-parts":[[2010,11,10]],"date-time":"2010-11-10T17:58:09Z","timestamp":1289411889000},"page":"1476-1481","source":"Crossref","is-referenced-by-count":129,"title":["Salivary gland carcinomas in children and adolescents: A population\u2010based study, with comparison to adult cases"],"prefix":"10.1002","volume":"33","author":[{"given":"Iyad","family":"Sultan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Rodriguez\u2013Galindo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sereen","family":"Al\u2010Sharabati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Guzzo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michela","family":"Casanova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Ferrari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,11,10]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-09-0638"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1159\/000099222"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/hed.20429"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.20637"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1054\/ijom.2002.0381"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/mpo.10168"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1177\/014556139807700511"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3468(94)90520-7"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-5876(94)90166-X"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1992.01880050018003"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1177\/000348949110001016"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(91)90014-4"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1930-2398.1988.tb00009.x"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1988.01860200082024"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100103779"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1159\/000275859"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19850415)55:8<1730::AID-CNCR2820550819>3.0.CO;2-J"},{"key":"e_1_2_6_19_2","unstructured":"Surveillance Epidemiology and End Results (SEER)Program (www.seer.cancer.gov) SEER*Stat Database: survival\u2010SEER17 Regs Limited\u2010Use Nov 2008 Sub (1973\u20132006) <Katrina\/Rita Population Adjustment> \u2010 Linked To County Attributes \u2010 Total U.S. 1969\u20132006 Counties National Cancer Institute DCCPS Surveillance Research Program Cancer Statistics Branch released April2009 based on the November 2008 submission."},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20910"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.22049"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2006.08.028"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.126.2.177"}],"container-title":["Head &amp; Neck"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhed.21629","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.21629","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T19:46:37Z","timestamp":1700595997000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hed.21629"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,11,10]]},"references-count":22,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2011,10]]}},"alternative-id":["10.1002\/hed.21629"],"URL":"https:\/\/doi.org\/10.1002\/hed.21629","archive":["Portico"],"relation":{},"ISSN":["1043-3074","1097-0347"],"issn-type":[{"value":"1043-3074","type":"print"},{"value":"1097-0347","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,11,10]]}}}