{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T04:12:24Z","timestamp":1784693544760,"version":"3.55.0"},"reference-count":48,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2010,12,6]],"date-time":"2010-12-06T00:00:00Z","timestamp":1291593600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2011,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Radiation\u2010induced temporal lobe necrosis is a rare and serious late complication in irradiated patients with nasopharyngeal carcinoma (NPC). Treatment of radiation\u2010induced temporal lobe necrosis with surgery has been seldom thoroughly investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively analyzed the clinical data of 14 patients with radiation\u2010induced temporal lobe necrosis treated with surgical intervention.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Radiation\u2010induced temporal lobe necrosis presented as obvious cystic formation or as heterogeneous enhanced nodule on MRI. Among 3 patients with <jats:sup>18<\/jats:sup>F\u2010fluorodeoxyglucose (<jats:sup>18<\/jats:sup>F\u2010FDG) PET\u2010CT scan, increased uptake of <jats:sup>18<\/jats:sup>F\u2010FDG was observed in 2 cases. Four patients were anesthestized nasotracheally and 1 was through tracheostomy during surgery because of other radiation complications, including trismus and skull base osteoradionecrosis. The temporal approach was applied in all cases, with the removal of bone flap in 11 patients. During follow\u2010up, 1 patient died of exhaustion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Surgery benefits selected patients with NPC with radiation\u2010induced temporal lobe necrosis. The goals of surgery are to relieve the increased intracranial pressure and to establish the accurate diagnosis. \u00a9 2010 Wiley Periodicals, Inc. Head Neck, 2010<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.21639","type":"journal-article","created":{"date-parts":[[2010,12,6]],"date-time":"2010-12-06T18:06:36Z","timestamp":1291658796000},"page":"1493-1500","source":"Crossref","is-referenced-by-count":36,"title":["Surgical management of radiation\u2010induced temporal lobe necrosis in patients with nasopharyngeal carcinoma: Report of 14 cases"],"prefix":"10.1002","volume":"33","author":[{"given":"Yong\u2010gao","family":"Mou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Sai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen\u2010ning","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang\u2010heng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan\u2010chun","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Da\u2010nian","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qun\u2010ying","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhong\u2010ping","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,12,6]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdf179"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-10-39"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1673.1997.tb00742.x"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.47.12.1338"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-510X(03)00007-8"},{"key":"e_1_2_6_7_2","first-page":"281","article-title":"Late cerebral radionecrosis","volume":"10","author":"Lorenzo ND","year":"1978","journal-title":"Surg Neurol"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/00001622-199006000-00024"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.213.3.r99dc07800"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(97)00580-4"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-8140(00)00336-4"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-8140(02)00370-5"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11517-007-0207-9"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1159\/000106026"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-8140(99)00177-2"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(03)00075-0"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2007.06.078"},{"key":"e_1_2_6_18_2","first-page":"129","article-title":"Ionizing radiation and vincristine: possible neurotoxic synergism","volume":"41","author":"Byfield JE","year":"1972","journal-title":"Radiol Clin Biol"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197502)35:2<306::AID-CNCR2820350203>3.0.CO;2-J"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2008.05.023"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10014-008-0233-9"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1159\/000061239"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1227\/00006123-199201000-00006"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(03)02278-9"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-9260(97)80130-4"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0720-048X(01)00328-X"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1007\/s003300000548"},{"key":"e_1_2_6_28_2","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1097\/00029330-200703020-00008","article-title":"PET\/CT imaging of delayed radiation encephalopathy following radiotherapy for nasopharyngeal carcinoma","volume":"120","author":"Wang XL","year":"2007","journal-title":"Chin Med J (Engl)"},{"issue":"11","key":"e_1_2_6_29_2","first-page":"1538","article-title":"Application of 18F\u2010FDG PET\/CT scan in following\u2010up of nasopharyngeal carcinoma after radiotherapy","volume":"23","author":"Yu DF","year":"2004","journal-title":"Ai Zheng"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.rlu.0000170039.14351.0b"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiographics.19.1.g99ja0761"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2491071753"},{"key":"e_1_2_6_33_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006123-199707000-00033"},{"key":"e_1_2_6_34_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19880415)61:8<1535::AID-CNCR2820610809>3.0.CO;2-E"},{"key":"e_1_2_6_35_2","doi-asserted-by":"publisher","DOI":"10.1159\/000056426"},{"key":"e_1_2_6_36_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19971115)80:10<2005::AID-CNCR19>3.0.CO;2-0"},{"key":"e_1_2_6_37_2","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1979.00790140004002"},{"key":"e_1_2_6_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2006.10.010"},{"key":"e_1_2_6_39_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.19.1866"},{"key":"e_1_2_6_40_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-009-9801-z"},{"key":"e_1_2_6_41_2","doi-asserted-by":"publisher","DOI":"10.1007\/s007010050454"},{"key":"e_1_2_6_42_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006123-200108000-00004"},{"key":"e_1_2_6_43_2","first-page":"487","article-title":"Cystic brain necrosis and temporal bone osteoradionecrosis after radiotherapy and surgery in a patient of ear carcinoma","volume":"67","author":"Wang PC","year":"2004","journal-title":"J Chin Med Assoc"},{"key":"e_1_2_6_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.surneu.2006.11.051"},{"key":"e_1_2_6_45_2","first-page":"685","article-title":"Recurrent cystic radiation necrosis of the brain","volume":"5","author":"Wong ET","year":"1998","journal-title":"Oncol Rep"},{"key":"e_1_2_6_46_2","first-page":"590","article-title":"Previously\u2010treated nasopharyngeal carcinoma with cystic lesions in the temporal lobe","volume":"45","author":"Rajendra T","year":"2004","journal-title":"Singapore Med J"},{"key":"e_1_2_6_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.surneu.2006.10.066"},{"key":"e_1_2_6_48_2","doi-asserted-by":"publisher","DOI":"10.1259\/bjr\/17942449"},{"key":"e_1_2_6_49_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000230435.71328.b9"}],"container-title":["Head &amp; Neck"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhed.21639","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.21639","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T19:46:17Z","timestamp":1700595977000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hed.21639"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,12,6]]},"references-count":48,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2011,10]]}},"alternative-id":["10.1002\/hed.21639"],"URL":"https:\/\/doi.org\/10.1002\/hed.21639","archive":["Portico"],"relation":{},"ISSN":["1043-3074","1097-0347"],"issn-type":[{"value":"1043-3074","type":"print"},{"value":"1097-0347","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,12,6]]}}}