{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T18:59:05Z","timestamp":1793473145479,"version":"4.5.0"},"reference-count":45,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2011,1,31]],"date-time":"2011-01-31T00:00:00Z","timestamp":1296432000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2011,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Nonsurgical modalities are sometimes advocated as the standard of care for advanced oropharyngeal tumors. Oncologic and functional results have been modest. The aim of our study was to evaluate outcomes of a minimally invasive approach, using transoral laser microsurgery (TLM) as the primary treatment for advanced oropharyngeal carcinoma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A prospectively assembled database of 204 patients with American Joint Committee on Cancer (AJCC) stages III and IV tonsil or tongue base cancer, treated primarily with TLM during 1996\u20132006 at 3 centers with minimum 2\u2010year follow\u2010up was analyzed. Survival, locoregional control, and swallowing status were recorded.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Mean follow\u2010up was 49 months and 79.4% of patients were alive. Three\u2010year overall survival, disease\u2010specific survival, and disease\u2010free survival were 86%, 88%, and 82%, respectively. Local control was 97%, and 87% of patients had normal swallowing or episodic dysphagia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>TLM as a primary treatment for advanced oropharyngeal malignancy confers excellent survival and swallowing proficiency. \u00a9 2011 Wiley Periodicals, Inc. Head Neck, 2011<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hed.21669","type":"journal-article","created":{"date-parts":[[2011,1,31]],"date-time":"2011-01-31T11:40:45Z","timestamp":1296474045000},"page":"1683-1694","source":"Crossref","is-referenced-by-count":333,"title":["Transoral laser microsurgery as primary treatment for advanced\u2010stage oropharyngeal cancer: A united states multicenter study"],"prefix":"10.1002","volume":"33","author":[{"given":"Bruce H.","family":"Haughey","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael L.","family":"Hinni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John R.","family":"Salassa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard 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