{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T04:15:53Z","timestamp":1783484153649,"version":"3.55.0"},"reference-count":28,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2011,6,17]],"date-time":"2011-06-17T00:00:00Z","timestamp":1308268800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2012,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>We describe a family harboring RET 790 mutation and review the role of prophylactic thyroidectomy for medullary thyroid carcinoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We evaluated in detail both clinical and biological follow\u2010up and reviewed literature reports.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 86 family members, 15 of 22 members screened harbored the 790 mutation. Abnormal calcitonin levels were found in 8\/15. Total thyroidectomy with lymph node dissection cured the 5 operated patients (range, 45\u201376 years). Tumor staging was pT1N0M0. Among 10 carriers who did not undergo surgery, 3 patients had abnormal calcitonin levels. For the others, calcitonin levels remained &lt;30 pg\/mL. Two asymptomatic carriers were older than 70 years. Four subjects were lost to follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In RET codon 790 mutations families, a case\u2010by\u2010case decision instead of systematic prophylactic thyroidectomy should be discussed. Difficulties of follow\u2010up should be taken into account and represent the main challenge. \u00a9 2011 Wiley Periodicals, Inc. Head Neck, 2012<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.21763","type":"journal-article","created":{"date-parts":[[2011,6,17]],"date-time":"2011-06-17T23:15:37Z","timestamp":1308352537000},"page":"493-498","source":"Crossref","is-referenced-by-count":11,"title":["Role of prophylactic thyroidectomy in RET 790 familial medullary thyroid carcinoma"],"prefix":"10.1002","volume":"34","author":[{"given":"H\u00e9l\u00e8ne","family":"Bihan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Baudin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taly","family":"Meas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Leboulleux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abir","family":"Al Ghuzlan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V\u00e9ronique","family":"Hannoteaux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Paul","family":"Travagli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrice","family":"Valleur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre\u2010Jean","family":"Guillausseau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R\u00e9gis","family":"Cohen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the French Group of Endocrine Tumors (GTE)","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,6,17]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"608","article-title":"Epithelioma of the thyroid secreting thyrocalcitonin [in French]","volume":"266","author":"Milhaud G","year":"1968","journal-title":"C R Acad Sci Hebd Seances Acad Sci D"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.1998.00392.x"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.86.12.8070"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa012915"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.85.2.6556"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncpendmet0717"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.86.3.1104"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-200211000-00006"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-004-7640-9"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1530\/eje.1.02216"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2008.03215.x"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00508-006-0636-8"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1159\/000185474"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1067\/S0039-6060(03)00157-0"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0009-8981(88)90365-8"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.1410468"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2001-12627"},{"key":"e_1_2_6_19_2","volume-title":"TNM classification of malignant tumours","author":"Sobin LH","year":"1997"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2008.0403"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.87.4.8403"},{"key":"e_1_2_6_22_2","first-page":"2870","article-title":"Biological properties of Ret with cysteine mutations correlate with multiple endocrine neoplasia type 2A, familial medullary thyroid carcinoma, and Hirschsprung's disease phenotype","volume":"57","author":"Ito S","year":"1997","journal-title":"Cancer Res"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1354\/vp.44-1-1"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.83.3.770"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1067\/msy.2002.128559"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.22244"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2002-021713"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2004-1836"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2009.0144"}],"container-title":["Head &amp; 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