{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T22:59:48Z","timestamp":1777330788489,"version":"3.51.4"},"reference-count":32,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2011,11,3]],"date-time":"2011-11-03T00:00:00Z","timestamp":1320278400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2013,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Leiomyosarcoma is a malignant tumor that originates in smooth muscle cells and is rarely found in the oral cavity. We present a case of high\u2010grade primary leiomyosarcoma in the mandible and discuss the diagnosis process.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The patient was a 64\u2010year\u2010old white man who had a slight increase in volume in the left\u2010side mandible with a radiolucent osteolytic image with the destruction of the mandibular cortex. Incisional biopsy and preoperative examination were performed, including cone beam CT and examination by immunohistochemistry that defined the histologic diagnosis of leiomyosarcoma. The patient underwent reconstruction with an osteocutaneous flap with microvascular anastomosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Two years after the surgery, there was no sign of recurrence of the lesion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The use of cone beam CT to define the limits of the lesion and the immunohistochemical findings were essential to establish the treatment plan. \u00a9 2011 Wiley Periodicals, Inc. Head Neck, 2013<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.21853","type":"journal-article","created":{"date-parts":[[2011,11,3]],"date-time":"2011-11-03T14:21:05Z","timestamp":1320330065000},"source":"Crossref","is-referenced-by-count":4,"title":["High\u2010grade primary leiomyosarcoma in the mandible: Diagnosis and treatment"],"prefix":"10.1002","volume":"35","author":[{"given":"Inara Carneiro Costa","family":"Rege","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N\u00e1dia Lago","family":"Costa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aline Carvalho","family":"Batista","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cl\u00f3vis Martins","family":"da Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandre Jo\u00e3o","family":"Meneghini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elismauro Francisco","family":"Mendon\u00e7a","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,11,3]]},"reference":[{"key":"e_1_2_4_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(77)90327-9"},{"key":"e_1_2_4_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.1700830229"},{"key":"e_1_2_4_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0278-2391(87)90242-4"},{"key":"e_1_2_4_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0278-2391(10)80118-1"},{"key":"e_1_2_4_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-0709(96)90077-0"},{"key":"e_1_2_4_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0278-2391(96)90176-7"},{"key":"e_1_2_4_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2006.12.015"},{"key":"e_1_2_4_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2005.06.018"},{"key":"e_1_2_4_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2009.01635.x"},{"key":"e_1_2_4_11_2","first-page":"160","article-title":"Low\u2010grade gingival leiomyosarcoma in a child","volume":"75","author":"Mendon\u00e7a EF","year":"2008","journal-title":"J Dent Child"},{"key":"e_1_2_4_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2007.05.005"},{"key":"e_1_2_4_13_2","first-page":"e56","article-title":"Primary leiomyosarcoma of the mandible. A case report","volume":"12","author":"Pinheiro JJV","year":"2007","journal-title":"Med Oral Patol Oral Cir Bucal"},{"key":"e_1_2_4_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ooe.2005.08.008"},{"key":"e_1_2_4_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-003-0233-4"},{"key":"e_1_2_4_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1368-8375(01)00047-1"},{"key":"e_1_2_4_17_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2559.2000.00814.x"},{"key":"e_1_2_4_18_2","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1999.70.1.84"},{"key":"e_1_2_4_19_2","doi-asserted-by":"publisher","DOI":"10.1159\/000331370"},{"key":"e_1_2_4_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1079-2104(99)70248-9"},{"key":"e_1_2_4_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1368-8375(98)80010-9"},{"key":"e_1_2_4_22_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100118572"},{"key":"e_1_2_4_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0278-2391(10)80326-X"},{"key":"e_1_2_4_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/0278-2391(91)90350-U"},{"key":"e_1_2_4_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/0278-2391(86)90157-6"},{"key":"e_1_2_4_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-9785(85)80015-6"},{"key":"e_1_2_4_27_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.1984.tb01436.x"},{"key":"e_1_2_4_28_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.1700830229"},{"key":"e_1_2_4_29_2","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.1944.0240"},{"key":"e_1_2_4_30_2","doi-asserted-by":"publisher","DOI":"10.1053\/joms.2001.22691"},{"key":"e_1_2_4_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2005.12.053"},{"key":"e_1_2_4_32_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.HP.0000326340.81581.1a"},{"key":"e_1_2_4_33_2","doi-asserted-by":"publisher","DOI":"10.1080\/02841850600647124"}],"container-title":["Head &amp; Neck"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhed.21853","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.21853","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T22:22:03Z","timestamp":1696890123000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hed.21853"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,11,3]]},"references-count":32,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,2]]}},"alternative-id":["10.1002\/hed.21853"],"URL":"https:\/\/doi.org\/10.1002\/hed.21853","archive":["Portico"],"relation":{},"ISSN":["1043-3074","1097-0347"],"issn-type":[{"value":"1043-3074","type":"print"},{"value":"1097-0347","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,11,3]]}}}