{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T18:26:18Z","timestamp":1791051978155,"version":"4.1.0"},"reference-count":27,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2011,10,10]],"date-time":"2011-10-10T00:00:00Z","timestamp":1318204800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2012,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>In oral cancer surgery, intraoperative optical imaging could help the surgeon to determine adequate tumor\u2010free margins.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Tumor\u2010specific near\u2010infrared fluorescence agents targeting epidermal growth factor receptor (CW800 EGF) or glucose transporter system (CW800 2\u2010DG) were administered to mice with tongue carcinoma and cervical lymph node metastases. Tumor growth was followed by bioluminescence imaging. Fluorescence signals were compared with a control group of healthy animals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Significantly higher fluorescence was found in tongue tumors and cervical lymph node metastases compared with that in control animals. Fluorescence correlated with histopathology. Tumor\u2010to\u2010background ratio of CW800 EGF in the tongue was 13.8 (SD = 6.1) and in the lymph nodes 15.7 (SD = 8.8). For CW800 2\u2010DG, the tumor\u2010to\u2010background ratio in the tongue was 4.6 (SD = 2.1) and in the lymph nodes 33.9 (SD = 18.4).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Optical imaging can be used to detect oral cancer and cervical lymph node metastases and could potentially improve complete surgical resection by real\u2010time image\u2010guided surgery. \u00a9 2011 Wiley Periodicals, Inc. Head Neck, 2012<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.21861","type":"journal-article","created":{"date-parts":[[2011,10,10]],"date-time":"2011-10-10T19:27:33Z","timestamp":1318274853000},"page":"1002-1008","source":"Crossref","is-referenced-by-count":45,"title":["Optical imaging of oral squamous cell carcinoma and cervical lymph node metastasis"],"prefix":"10.1002","volume":"34","author":[{"given":"Stijn","family":"Keereweer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeroen D. F.","family":"Kerrebijn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel M.","family":"Mol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Sven D.","family":"Mieog","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pieter B. A. 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