{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T15:41:51Z","timestamp":1777563711391,"version":"3.51.4"},"reference-count":19,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2011,11,3]],"date-time":"2011-11-03T00:00:00Z","timestamp":1320278400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2012,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Patients with T4 laryngeal cancers, including those with large\u2010volume (cartilage or tongue\u2010base invasion) lesions, are often excluded from organ\u2010preservation trials due to expectations of inferior outcome in terms of survival and function. We hypothesize that such patients indeed have acceptable survival and function when treated with organ\u2010preservation strategies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Retrospective analysis of prospectively collected data of a cohort of patients with T4 laryngeal cancer was carried out. Follow\u2010up ranged from 0.18 to 15.6 years. All T4 laryngeal cancer patients who were enrolled in the University of Chicago concomitant chemoradiotherapy protocols from 1994 to the present were reviewed. This study was composed of 80 newly diagnosed T4 laryngeal cancer patients. Efficacy of treatment was determined through evaluations of survival and function. Survival was evaluated via Kaplan\u2013Meier methods. Swallowing function was evaluated by an oropharyngeal motility (OPM) study and swallowing scores were assigned. Higher scores reflected increasing swallowing dysfunction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Fifty\u2010five of 80 patients (\u223c69%) had documented large\u2010volume tumor. Two\u2010 and 5\u2010year overall survivals were 60.0% and 48.7%, respectively. Disease\u2010specific 2\u2010 and 5\u2010year survivals for the group were 80.1% and 71.3%, and 79.4 and 74.3%, respectively, for the 55 patients with large volume status. Progression\u2010free survival rates were 52.6% and 47.6%. Forty\u2010four of 65 patients (\u223c68%) with OPM data had a Swallowing Performance Status Scale (SPSS) score of \u22645, indicating various degrees of swallowing abnormalities not requiring a gastrostomy tube. This is a functional\u2010preservation rate of 67.7%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Chemoradiation for patients with T4 laryngeal cancer appears to be an effective and reasonable option, particularly in light of the satisfactory survival and function\u2010preservation rates. \u00a9 2011 Wiley Periodicals, Inc. Head Neck, 2012<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hed.21888","type":"journal-article","created":{"date-parts":[[2011,11,3]],"date-time":"2011-11-03T10:19:39Z","timestamp":1320315579000},"page":"1162-1167","source":"Crossref","is-referenced-by-count":22,"title":["Chemoradiation for patients with large\u2010volume laryngeal cancers"],"prefix":"10.1002","volume":"34","author":[{"given":"Kerstin M.","family":"Stenson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ellen","family":"MacCracken","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rangesh","family":"Kunnavakkam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ezra E.","family":"W. Cohen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louis D.","family":"Portugal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victoria","family":"Villaflor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tanguy","family":"Seiwert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth","family":"Blair","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel J.","family":"Haraf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph K.","family":"Salama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Everett E.","family":"Vokes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,11,3]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"1685","article-title":"The Department of Veterans Affairs Laryngeal Cancer Study Group","volume":"324","author":"Induction chemotherapy plus radiation compared with surgery plus radiation in patients with advanced laryngeal cancer","year":"1991","journal-title":"New Engl J Med"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/hed.20715"},{"key":"e_1_2_6_4_2","unstructured":"National Comprehensive Cancer Network (NCCN). 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