{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T01:49:40Z","timestamp":1785548980765,"version":"3.56.0"},"reference-count":37,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2011,11,3]],"date-time":"2011-11-03T00:00:00Z","timestamp":1320278400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2012,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>To determine whether 2\u2010[<jats:sup>18<\/jats:sup>F]fluoro\u20102\u2010deoxy\u2010D\u2010glucose positron emission tomography (FDG\u2010PET) could serve as a useful technique predicting tumor hypoxia and prognosis in tongue cancer, we assessed the relationship between FDG uptake and the levels of hypoxia\u2010related markers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Tumor uptake of FDG in 33 patients with T2 tongue cancer was assessed by measuring maximum standardized uptake values (SUVmax). Expression of hypoxia\u2010inducible factor (HIF)\u20101\u03b1, carbonic anhydrase (CA)\u20109, glucose transporter (GLUT)\u20101, and erythropoietin receptor (EPOR), was determined by immunohistochemical staining. Correlation between SUVmax and the expression of hypoxia\u2010related markers was assessed and multivariate analysis was performed to determine what parameters affected clinical outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We observed strong correlations between SUVmax and expression of HIF\u20101\u03b1 (<jats:italic>p<\/jats:italic> &lt; .05), CA\u20109 (<jats:italic>p<\/jats:italic> &lt; .01), and GLUT\u20101 (<jats:italic>p<\/jats:italic> &lt; .01). SUVmax, HIF\u20101\u03b1 expression, and tumor grade were significant independent predictors of disease\u2010free survival (DFS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>SUVmax may be a good noninvasive biomarker for prediction of hypoxic status and prognosis of patients with T2 tongue cancer. \u00a9 2011 Wiley Periodicals, Inc. Head Neck, 2011<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.21945","type":"journal-article","created":{"date-parts":[[2011,11,3]],"date-time":"2011-11-03T14:21:12Z","timestamp":1320330072000},"page":"1395-1402","source":"Crossref","is-referenced-by-count":50,"title":["Role of FDG\u2010PET as a biological marker for predicting the hypoxic status of tongue cancer"],"prefix":"10.1002","volume":"34","author":[{"given":"Myung Woul","family":"Han","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hee Jin","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyung\u2013Ja","family":"Cho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae 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