{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T21:46:45Z","timestamp":1781819205532,"version":"3.54.5"},"reference-count":26,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2012,1,17]],"date-time":"2012-01-17T00:00:00Z","timestamp":1326758400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2012,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>High rates of positive surgical margins are reported after a maxillectomy. A large part of tumors that are preoperatively considered \u201coperable\u201d can thus not be resected with tumor\u2010free margins.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a retrospective study on medical files of 69 patients that underwent maxillectomy as primary treatment for a squamous cell carcinoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>More than one third (39%) of all resections performed is incomplete, with dorsal or dorsocranial\u2010positive surgical margins in two thirds. Correlation of tumor extension on preoperative imaging to surgical margins status revealed that dorsal and cranial tumor extension were significant prognostic factors for tumor positive surgical margins (<jats:italic>p<\/jats:italic> = .006 and <jats:italic>p<\/jats:italic> = .031, respectively). Positive margins were associated with a 2\u2010fold increased risk of death (hazard ratio, 2.4; 95% confidence interval, 1.2\u20134.9).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Cranial or dorsal tumor extension on preoperative imaging was a significant risk factor for positive surgical margins after maxillectomy with significant negative influence on overall survival. \u00a9 2012 Wiley Periodicals, Inc. Head Neck, 2012<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.21987","type":"journal-article","created":{"date-parts":[[2012,1,17]],"date-time":"2012-01-17T11:49:10Z","timestamp":1326800950000},"page":"1652-1656","source":"Crossref","is-referenced-by-count":27,"title":["Preoperative imaging and surgical margins in maxillectomy patients"],"prefix":"10.1002","volume":"34","author":[{"given":"Anne Marijn","family":"Kreeft","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludwig E.","family":"Smeele","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Coen R. N.","family":"Rasch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Hauptmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derk H. 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