{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T10:34:12Z","timestamp":1790937252988,"version":"4.1.0"},"reference-count":46,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,2,6]],"date-time":"2012-02-06T00:00:00Z","timestamp":1328486400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The prognostic significance of volume\u2010based metabolic parameters measured by <jats:sup>18<\/jats:sup>F\u2010fluorodeoxyglucose positron emission tomography\/CT (<jats:sup>18<\/jats:sup>F\u2010FDG PET\/CT) is not established. We evaluated the prognostic value of metabolic parameters in patients with squamous cell carcinoma (SCC) of the tonsil.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We enrolled a total of 69 patients with SCC of the tonsil who underwent pretreatment <jats:sup>18<\/jats:sup>F\u2010FDG PET\/CT. We measured maximum standardized uptake value (SUV<jats:sub>max<\/jats:sub>), metabolic tumor volume (MTV), total lesion glycolysis (TLG), and asymmetry indices (of SUV<jats:sub>max<\/jats:sub>, MTV, and TLG). The prognostic significance of these parameters and clinical variables was assessed by Cox proportional hazards regression analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Multivariate analyses with adjustments for age, sex, and American Joint Committee on Cancer stage showed that only TLG (hazard ratio = 1.020, 95% confidence interval 1.003\u20131.037, <jats:italic>p<\/jats:italic> = .023) was an independent predictive factor associated with decreased overall survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>TLG is a significant independent metabolic prognostic factor for overall survival in patients with SCC of the tonsil. \u00a9 2012 Wiley Periodicals, Inc. Head Neck, 2013<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.22904","type":"journal-article","created":{"date-parts":[[2012,2,6]],"date-time":"2012-02-06T06:31:30Z","timestamp":1328509890000},"page":"15-22","source":"Crossref","is-referenced-by-count":107,"title":["Prognostic value of <sup>18<\/sup>F\u2010FDG PET\/CT in patients with squamous cell carcinoma of the tonsil: Comparisons of volume\u2010based metabolic parameters"],"prefix":"10.1002","volume":"35","author":[{"given":"Seung Hwan","family":"Moon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joon Young","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hwan 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