{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T04:45:50Z","timestamp":1778647550339,"version":"3.51.4"},"reference-count":23,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2012,1,20]],"date-time":"2012-01-20T00:00:00Z","timestamp":1327017600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>There are limited data on the role of laser\u2010assisted surgery for early glottic cancer in elderly patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective study was conducted on a series of 130 consecutive cases of early glottic carcinoma occurring in elderly patients (&gt;65 years old) treated with CO<jats:sub>2<\/jats:sub> laser surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The overall and disease\u2010specific survival rates were 87.7% and 99.2%, respectively. The rates of local disease control after primary laser surgery, ultimate local control with laser alone, and laryngeal preservation were 84.6%, 93.8%, and 96.9%, respectively. A shorter disease\u2010free survival (DFS) was associated with the involvement of 1 or more specific laryngeal regions (arytenoids, ventricle, anterior commissure, vocal muscle, subglottis) (<jats:italic>p<\/jats:italic> = .01) and the status of the surgical margins (<jats:italic>p<\/jats:italic> = .002); on multivariate analysis, only the latter remained prognostically significant vis\u2010\u00e0\u2010vis the DFS (<jats:italic>p<\/jats:italic> = .002).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Even in elderly patients with early glottic carcinoma, endoscopic laser surgery is an effective treatment. \u00a9 2012 Wiley Periodicals, Inc. <jats:italic>Head Neck<\/jats:italic>, 2012<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.22907","type":"journal-article","created":{"date-parts":[[2012,1,21]],"date-time":"2012-01-21T04:17:33Z","timestamp":1327119453000},"page":"1804-1809","source":"Crossref","is-referenced-by-count":22,"title":["CO<sub>2<\/sub> laser surgery in elderly patients with glottic carcinoma: Univariate and multivariate analyses of results"],"prefix":"10.1002","volume":"34","author":[{"given":"Marco","family":"Lucioni","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andy","family":"Bertolin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Rizzotto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daria","family":"Accordi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luciano","family":"Giacomelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gino","family":"Marioni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,1,20]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2008.11.002"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1186\/1758-3284-3-3"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/lary.21226"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2006.07.002"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD002027"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-011-1695-7"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-009-1135-0"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-007-0279-z"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-003-0674-z"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4757-3656-4"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004050050228"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21292"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/00130404-200401000-00012"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(94)90310-7"},{"key":"e_1_2_6_16_2","first-page":"169","article-title":"Laser surgery for early glottic cancer in elderly","volume":"30","author":"Ansarin M","year":"2010","journal-title":"Acta Otorhinolaryngol Ital"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1001\/archoto.2009.10"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000251165.48830.89"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21278"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2009.08.066"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21262"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-008-0803-9"},{"key":"e_1_2_6_23_2","article-title":"Transoral laser surgery versus radiotherapy: systematic review and meta\u2010analysis for treatment options of T1a glottic cancer","author":"Abdurehim Y","year":"2011","journal-title":"Head Neck"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21027"}],"container-title":["Head &amp; 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