{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T05:30:08Z","timestamp":1791178208580,"version":"4.1.0"},"reference-count":49,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2012,7,12]],"date-time":"2012-07-12T00:00:00Z","timestamp":1342051200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Juvenile nasopharyngeal angiofibroma (JNA) is a highly vascular tumor with some characteristics resembling those of vascular malformations. The significance of different growth and angiogenesis promoting factors for the etiology of JNA remains unsolved.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We analyzed the immunoexpressions of glucose transporter 1 (GLUT\u20101), tenascin\u2010C (TNC), and syndecan\u20102 in a series of 27 patients with JNA and compared these with each other and the clinical data to investigate their possible connections and role in the angiogenesis and growth of JNA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We found that frequent stromal TNC expression had a strong correlation with vessel density and tumor stage and endothelial GLUT\u20101 expression, when present, correlated with higher tumor stage. Stromal TNC and stromal GLUT\u20101 expressions were also found to correlate with each other.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The immunoexpression of stromal TNC correlated with vascular density and higher tumors stage, which supports the idea of TNC having a role in the tumorigenesis of JNA putatively by promoting angiogenesis. \u00a9 2012 Wiley Periodicals, Inc. Head Neck, 2013<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.23083","type":"journal-article","created":{"date-parts":[[2012,7,13]],"date-time":"2012-07-13T07:42:08Z","timestamp":1342165328000},"page":"1036-1042","source":"Crossref","is-referenced-by-count":15,"title":["Tenascin\u2010C, GLUT\u20101, and syndecan\u20102 expression in juvenile nasopharyngeal angiofibroma: Correlations to vessel density and tumor stage"],"prefix":"10.1002","volume":"35","author":[{"given":"Suvi","family":"Renkonen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P\u00e4ivi","family":"Heikkil\u00e4","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caj","family":"Haglund","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antti A.","family":"M\u00e4kitie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaana","family":"Hagstr\u00f6m","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,7,12]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/00125480-200007010-00006"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1067\/mhn.2000.105061"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2005.06.007"},{"key":"e_1_2_6_5_2","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.5858\/2003-127-1480-GFARIJ","article-title":"Growth factors and receptors in juvenile nasopharyngeal angiofibroma and nasal polyps: an immunohistochemical study","volume":"127","author":"Zhang PJ","year":"2003","journal-title":"Arch Pathol Lab Med"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-010-1010-9"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2008.03.002"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.pai.0000162003.43334.c7"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2011.03806.x"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2010.10086.x"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1006\/gyno.2002.6745"},{"key":"e_1_2_6_12_2","first-page":"59","article-title":"Benign vascular proliferations\u2014an immunohistochemical and comparative study","volume":"55","author":"Dyduch G","year":"2004","journal-title":"Pol J Pathol"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjps.2004.05.029"},{"key":"e_1_2_6_14_2","first-page":"167","article-title":"HIF transcription factor expression and induction of hypoxic response genes in a retroperitoneal angiosarcoma","volume":"24","author":"Rathmell WK","year":"2004","journal-title":"Anticancer Res"},{"key":"e_1_2_6_15_2","first-page":"3","article-title":"The tenascin gene family","volume":"2","author":"Chiquet\u2013Ehrismann R","year":"1994","journal-title":"Perspect Dev Neurobiol"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0177(200006)218:2<235::AID-DVDY2>3.0.CO;2-G"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2008.12.012"},{"key":"e_1_2_6_18_2","first-page":"3051","article-title":"Tenascin\u2010C expression and its prognostic significance in oral and pharyngeal squamous cell carcinoma","volume":"23","author":"Atula T","year":"2003","journal-title":"Anticancer Res"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1998.714"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0463.2006.apm_249.x"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2004.018432"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1159\/000113490"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1159\/000069305"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2006.10.014"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.matbio.2006.07.003"},{"key":"e_1_2_6_26_2","first-page":"378","article-title":"Syndecan\u20101 and tenascin expression in cystic tumors of the pancreas","volume":"10","author":"Kyl\u00e4np\u00e4\u00e4 L","year":"2009","journal-title":"JOP"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/aja.2010.143"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1111\/IGC.0b013e3181e02faa"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2005.08.012"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2008.11.016"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-010-1383-z"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6605544"},{"key":"e_1_2_6_33_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3639.2009.00357.x"},{"key":"e_1_2_6_34_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.2125"},{"key":"e_1_2_6_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2011.02.005"},{"key":"e_1_2_6_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.acthis.2010.07.003"},{"key":"e_1_2_6_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2006.02.017"},{"key":"e_1_2_6_38_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02893856"},{"key":"e_1_2_6_39_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.11509"},{"key":"e_1_2_6_40_2","doi-asserted-by":"publisher","DOI":"10.1159\/000094819"},{"key":"e_1_2_6_41_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2006.01344.x"},{"key":"e_1_2_6_42_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5829.2010.00233.x"},{"key":"e_1_2_6_43_2","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgn066"},{"key":"e_1_2_6_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2010.09.022"},{"key":"e_1_2_6_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2008.09.102"},{"key":"e_1_2_6_46_2","doi-asserted-by":"publisher","DOI":"10.4161\/cc.9.9.11358"},{"key":"e_1_2_6_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2011.01.017"},{"key":"e_1_2_6_48_2","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.134.11.1170"},{"key":"e_1_2_6_49_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-006-0202-z"},{"key":"e_1_2_6_50_2","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7827-2-3"}],"container-title":["Head &amp; Neck"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhed.23083","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.23083","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T19:07:06Z","timestamp":1697483226000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hed.23083"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,7,12]]},"references-count":49,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2013,7]]}},"alternative-id":["10.1002\/hed.23083"],"URL":"https:\/\/doi.org\/10.1002\/hed.23083","archive":["Portico"],"relation":{},"ISSN":["1043-3074","1097-0347"],"issn-type":[{"value":"1043-3074","type":"print"},{"value":"1097-0347","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,7,12]]}}}