{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T07:10:48Z","timestamp":1696921848220},"reference-count":14,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2012,9,18]],"date-time":"2012-09-18T00:00:00Z","timestamp":1347926400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>We present our experience with the use of an immunocompetent medium\u2010sized animal model of tongue cancer that may be suitable for imaging and surgical studies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A New Zealand white rabbit model of tongue cancer was created by injecting a VX tumor cell suspension grown in culture into the tongue of our model. The tumor was examined 7 days following implantation by physical examination, photography, and <jats:sup>18<\/jats:sup>fluoro 2\u2010deoxyglucose\u2013positron emission tomography (FDG\u2010PET). At 12 days postimplantation, the model was again studied as described above prior to euthanization, and then tongue excision and bilateral neck dissections were performed. All tissue was examined by histology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We confirmed a successful orthotopic tongue cancer model that resulted in cervical nodal metastases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This model may be a useful model of orthotopic head and neck cancer for future surgical or imaging research. \u00a9 2012 Wiley Periodicals, Inc. Head Neck, 2013<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.23105","type":"journal-article","created":{"date-parts":[[2012,9,18]],"date-time":"2012-09-18T10:39:23Z","timestamp":1347964763000},"page":"1119-1123","source":"Crossref","is-referenced-by-count":4,"title":["Orthotopic VX rabbit tongue cancer model with FDG\u2013PET and histologic characterization"],"prefix":"10.1002","volume":"35","author":[{"suffix":"Jr","given":"Brendan C.","family":"Stack","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Ye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Twyla B.","family":"Bartel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gal","family":"Shafirstein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chien","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric","family":"Siegel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bipin","family":"Singh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samta","family":"Thacker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Val J.","family":"Lowe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vivek","family":"Nagarkar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,9,18]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.62.4.523"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.71.6.813"},{"key":"e_1_2_7_4_2","doi-asserted-by":"crossref","first-page":"152","DOI":"10.3109\/00016488909125513","article-title":"The rabbit VX tumour as a model for carcinomas of the tongue and larynx","volume":"108","author":"Jefferis AF","year":"1989","journal-title":"Acta Otolaryngol (Stockh)"},{"key":"e_1_2_7_5_2","first-page":"1785","article-title":"Intravenous chemotherapy with cisplatin for regional lymph node metastases of auricular VX2 carcinoma","volume":"24","author":"D\u00fcnne AA","year":"2004","journal-title":"Anticancer Res"},{"key":"e_1_2_7_6_2","first-page":"4209","article-title":"The auricular VX2 carcinoma: feasibility of complete tumor resection","volume":"25","author":"Sapundzhiev N","year":"2005","journal-title":"Anticancer Res"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1258\/002367703762226674"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1586\/era.10.108"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-198211000-00001"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/lary.21404"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.3109\/00016480903253595"},{"key":"e_1_2_7_12_2","first-page":"2019","article-title":"Delivery of superparamagnetic nanoparticles for local chemotherapy after intraarterial infusion and magnetic drug targeting","volume":"27","author":"Alexiou C","year":"2007","journal-title":"Anticancer Res"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.3348\/kjr.2007.8.1.9"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-008-1192-6"},{"key":"e_1_2_7_15_2","first-page":"669","article-title":"American Veterinary Medical Association","volume":"281","author":"2000 Report of the AVMA Panel on Euthanasia","year":"2001","journal-title":"J Am Veterinary Med Assoc"}],"container-title":["Head &amp; Neck"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhed.23105","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.23105","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T20:10:01Z","timestamp":1696882201000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hed.23105"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,9,18]]},"references-count":14,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2013,8]]}},"alternative-id":["10.1002\/hed.23105"],"URL":"https:\/\/doi.org\/10.1002\/hed.23105","archive":["Portico"],"relation":{},"ISSN":["1043-3074","1097-0347"],"issn-type":[{"value":"1043-3074","type":"print"},{"value":"1097-0347","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,9,18]]}}}