{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T03:37:04Z","timestamp":1788233824053,"version":"build-2803163510"},"reference-count":30,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2012,9,13]],"date-time":"2012-09-13T00:00:00Z","timestamp":1347494400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2013,10]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Oral cancer is the most common cancer in Indian males and is the third most common cancer in Indian females. Tobacco, alcohol, areca nut, and human papillomavirus (HPV) are the common etiologic factors. Each of these agents follows a unique model of carcinogenesis that leads to a certain distinct presentation and behavior. For example, HPV is strongly associated with oropharyngeal cancers in younger age and is known to have a better outcome and specific histopathologic characteristics. A high incidence of oral submucous fibrosis (OSMF) is linked to areca nut (group 1 human carcinogen) chewing in the Indian subcontinent.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We prospectively studied 371 consecutive patients with proven squamous cell carcinoma of the oral cavity. Of these, 112 patients had oral cancer with OSMF and 259 had oral cancer without OSMF. All patients underwent standard management and their clinicopathologic findings were recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We found that patients of oral cancer with OSMF are younger males with better prognostic factors such as better grade of tumor differentiation, lesser incidence of nodal metastases, and extracapsular spread. This difference was maintained even after matching for stage. We also report that presence of OSMF is an independent factor influencing nodal metastases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Based on these findings we propose that oral cancers with OSMF constitute a clinicopathologically distinct disease. Since all patients with OSMF had chewed areca nut with or without smokeless tobacco, we believe that the differences in the 2 groups emanate from differential mechanisms of areca nut carcinogenesis. \u00a9 2012 Wiley Periodicals, Inc. <jats:italic>Head Neck<\/jats:italic> 35: 1404\u20131409, 2013<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.23143","type":"journal-article","created":{"date-parts":[[2012,9,13]],"date-time":"2012-09-13T06:59:04Z","timestamp":1347519544000},"page":"1404-1409","source":"Crossref","is-referenced-by-count":96,"title":["Oral squamous cell carcinoma arising in background of oral submucous fibrosis: a clinicopathologically distinct disease"],"prefix":"10.1002","volume":"35","author":[{"given":"Pankaj","family":"Chaturvedi","sequence":"first","affiliation":[{"name":"Department of Head and Neck Oncosurgery Tata Memorial Hospital Parel Mumbai Maharashtra India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sagar S.","family":"Vaishampayan","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Oncosurgery Tata Memorial Hospital Parel Mumbai Maharashtra India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sudhir","family":"Nair","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Oncosurgery Tata Memorial Hospital Parel Mumbai Maharashtra India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepa","family":"Nair","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Oncosurgery Tata Memorial Hospital Parel Mumbai Maharashtra India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. P.","family":"Agarwal","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Oncosurgery Tata Memorial Hospital Parel Mumbai Maharashtra India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. V.","family":"Kane","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Oncosurgery Tata Memorial Hospital Parel Mumbai Maharashtra India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prashant","family":"Pawar","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Oncosurgery Tata Memorial Hospital Parel Mumbai Maharashtra India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sourav","family":"Datta","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Oncosurgery Tata Memorial Hospital Parel Mumbai Maharashtra India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,9,13]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"1","volume-title":"Contemporary issues in oral cancer","author":"Notani PN","year":"2000"},{"key":"e_1_2_6_3_1","first-page":"464","article-title":"Global variation in cancer incidence and mortality","volume":"81","author":"Notani PN","year":"2001","journal-title":"Curr Sci"},{"key":"e_1_2_6_4_1","series-title":"Cancer incidence in five continents","author":"Parkin DM","year":"2002"},{"key":"e_1_2_6_5_1","unstructured":"An atlas of cancer in India. Available from:http:\/\/www.canceratlasindia.org\/ map.htm."},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2008.06.002"},{"key":"e_1_2_6_7_1","series-title":"IARC Monographs on the Evaluation of the Carcinogenic Risk to Humans","volume-title":"Tobacco smoking","year":"1986"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1190"},{"key":"e_1_2_6_9_1","series-title":"IARC Monographs on the Evaluation of the Carcinogenic Risk to Humans","volume-title":"Alcohol drinking","year":"1988"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1368-8375(01)00003-3"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arcmed.2007.08.003"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.59.6.959"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.20195"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0266-4356(98)90707-0"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2010.07.010"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0912217"},{"key":"e_1_2_6_17_1","series-title":"IARC Monograph on the Evaluation of Carcinogenic Risk of Chemicals to Humans","volume-title":"Tobacco Habits Other Than Smoking: Betel Quid and Areca\u2010Nut Chewing, and Some Related Nitrosamines","year":"1985"},{"key":"e_1_2_6_18_1","series-title":"IARC Monographs on the Evaluation of Carcinogenic Risks to Humans","volume-title":"Betel\u2010Quid and Areca\u2010Nut Chewing and Some Areca\u2010Nut\u2013Derived Nitrosamines","author":"World Health Organization International Agency for Research on Cancer","year":"2004"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(66)90367-7"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bdj.4805876"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2005.08.005"},{"key":"e_1_2_6_22_1","first-page":"113","article-title":"Oral submucous fibrosis in India: a new epidemic?","volume":"11","author":"Gupta PC","year":"1998","journal-title":"Natl Med J India"},{"key":"e_1_2_6_23_1","first-page":"299","article-title":"Oral submucous fibrosis, areca nut and pan masala use: a case\u2010control study","volume":"11","author":"Hazare VK","year":"1998","journal-title":"Natl Med J India"},{"key":"e_1_2_6_24_1","first-page":"377","article-title":"Malignant transformation rate in oral submucous fibrosis over a 17 year period","volume":"25","author":"Murti PR","year":"1997","journal-title":"Community Dent Oral Epidemiol"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2007.00582.x"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10006-010-0219-8"},{"key":"e_1_2_6_27_1","first-page":"224","article-title":"Oral submucous fibrosis as a precancerous condition","volume":"92","author":"Pindborg JJ","year":"1984","journal-title":"Scand J Dent Res"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19900701)66:1<109::AID-CNCR2820660120>3.0.CO;2-A"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1368-8375(02)00030-1"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2009.10.054"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0528.2005.00251.x"}],"container-title":["Head &amp; Neck"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhed.23143","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.23143","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T18:14:15Z","timestamp":1696356855000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hed.23143"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,9,13]]},"references-count":30,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2013,10]]}},"alternative-id":["10.1002\/hed.23143"],"URL":"https:\/\/doi.org\/10.1002\/hed.23143","archive":["Portico"],"relation":{},"ISSN":["1043-3074","1097-0347"],"issn-type":[{"value":"1043-3074","type":"print"},{"value":"1097-0347","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,9,13]]}}}