{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T04:52:12Z","timestamp":1793163132691,"version":"4.5.0"},"reference-count":28,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2012,9,24]],"date-time":"2012-09-24T00:00:00Z","timestamp":1348444800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2013,10]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Primary squamous cell carcinoma (SCC) of the thyroid gland is a rare malignancy that presents with advanced disease and poor prognosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A 75\u2010year\u2010old woman with a history of Hashimoto thyroiditis presented with 6 months of dysphagia and stridor. Imaging revealed a thyroid mass invading the larynx. Primary SCC of the thyroid was diagnosed by histopathologic and immunohistochemical evaluation. Total thyroidectomy, total laryngectomy, bilateral modified neck dissection, and adjuvant radiotherapy (RT) were performed. Radiologic follow\u2010up at 21 months demonstrated no disease and total length of survival was 31 months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Despite an aggressive T4aN0M0 tumor, survival in this case was more than double the median survival rate previously reported. Concomitant Hashimoto thyroiditis is rare and histopathologic and immunohistochemical evaluation is imperative for an accurate diagnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The case and literature reported here support that a thorough diagnostic workup of primary SCC of the thyroid with aggressive locoregional surgery and adjuvant RT may improve the length of survival. \u00a9 2012 Wiley Periodicals, Inc.<jats:sup>\u2020<\/jats:sup> <jats:italic>Head Neck<\/jats:italic> 35: E299\u2013E303, 2013<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.23152","type":"journal-article","created":{"date-parts":[[2012,9,24]],"date-time":"2012-09-24T07:09:18Z","timestamp":1348470558000},"source":"Crossref","is-referenced-by-count":25,"title":["Primary squamous cell carcinoma of the thyroid gland: A case report and review"],"prefix":"10.1002","volume":"35","author":[{"given":"Merica","family":"Shrestha","sequence":"first","affiliation":[{"name":"Department of Medicine, Endocrinology, Diabetes and Metabolism Service Dwight D. Eisenhower Army Medical Center 300 Hospital Road Fort Gordon Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shankar K.","family":"Sridhara","sequence":"additional","affiliation":[{"name":"Department of Surgery, Otolaryngology \u2013 Head and Neck Surgery Service Dwight D. Eisenhower Army Medical Center 300 Hospital Road Fort Gordon Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonard J.","family":"Leo","sequence":"additional","affiliation":[{"name":"Department of Pathology Walter Reed National Military Medical Center 8901 Rockville Pike Bethesda Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"III","given":"George L.","family":"Coppit","sequence":"additional","affiliation":[{"name":"Department of Surgery, Otolaryngology - Head and Neck Surgery Service Walter Reed National Military Medical Center 8901 Rockville Pike Bethesda Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole M.","family":"Ehrhardt","sequence":"additional","affiliation":[{"name":"Department of Medicine, Endocrinology, Diabetes, and Metabolism Service Fort Belvoir Community Hospital 9300 DeWitt Loop Fort Belvoir Virginia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,9,24]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2303.2010.00828.x"},{"key":"e_1_2_4_3_1","first-page":"925","article-title":"Canadian survey of thyroid cancer","volume":"132","author":"Simpson WJ","year":"1985","journal-title":"Can Med Assoc J"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215110002070"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02470671"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1053\/ejso.1999.0715"},{"key":"e_1_2_4_7_1","volume-title":"Robbins and Cotran pathologic basis of disease, professional edition","author":"Kumar V","year":"2010"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-197806000-00002"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.10178"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3880129"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2006.16.89"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2559.2001.01207.x"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200101000-00004"},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.1309\/21TW-2NDG-JRK4-PFJX"},{"key":"e_1_2_4_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200302000-00002"},{"key":"e_1_2_4_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200608000-00010"},{"key":"e_1_2_4_17_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1827.2003.01472.x"},{"key":"e_1_2_4_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3880098"},{"key":"e_1_2_4_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/030089160709300522"},{"key":"e_1_2_4_20_1","doi-asserted-by":"publisher","DOI":"10.2350\/06-04-0073.1"},{"key":"e_1_2_4_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00595-005-3107-3"},{"key":"e_1_2_4_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2009.05.003"},{"key":"e_1_2_4_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(88)80169-7"},{"key":"e_1_2_4_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.2930190111"},{"key":"e_1_2_4_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19801015)46:8<1833::AID-CNCR2820460822>3.0.CO;2-G"},{"key":"e_1_2_4_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19811101)48:9<2080::AID-CNCR2820480927>3.0.CO;2-N"},{"key":"e_1_2_4_27_1","doi-asserted-by":"publisher","DOI":"10.1053\/ejso.2001.1180"},{"key":"e_1_2_4_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2005.05.004"},{"key":"e_1_2_4_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1479-666X(07)80010-2"}],"container-title":["Head &amp; Neck"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhed.23152","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.23152","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T18:15:24Z","timestamp":1696356924000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hed.23152"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,9,24]]},"references-count":28,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2013,10]]}},"alternative-id":["10.1002\/hed.23152"],"URL":"https:\/\/doi.org\/10.1002\/hed.23152","archive":["Portico"],"relation":{},"ISSN":["1043-3074","1097-0347"],"issn-type":[{"value":"1043-3074","type":"print"},{"value":"1097-0347","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,9,24]]}}}