{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T00:45:08Z","timestamp":1772585108325,"version":"3.50.1"},"reference-count":26,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2013,3,8]],"date-time":"2013-03-08T00:00:00Z","timestamp":1362700800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The purpose of this study was to examine endoglin (CD105) expression on microvessel endothelial cells (ECs) in juvenile nasopharyngeal angiofibroma (JNA) and its relationship with recurrence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Immunohistochemistry was performed to detect CD105 expression in a tissue microarray from 70 patients with JNA. Correlation between CD105 expression on microvessel ECs and clinicopathological features, as well as tumor recurrence, were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Immunohistochemistry revealed CD105 expression on ECs but not in stroma of patients with JNA. Chi\u2010square analysis indicated CD105\u2010based microvessel density (MVD) was correlated with JNA recurrence (<jats:italic>p<\/jats:italic> = .013). Univariate and multivariate analyses determined that MVD was a significant predictor of time to recurrence (<jats:italic>p<\/jats:italic> = .009). The CD105\u2010based MVD was better for predicting disease recurrence (AUROC: 0.673; <jats:italic>p<\/jats:italic> = .036) than other clinicopathological features.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>MVD is a useful predictor for poor prognosis of patients with JNA after curative resection. Angiogenesis, which may play an important role in the occurrence and development of JNA, is therefore a potential therapeutic target for JNA. \u00a9 2013 Wiley Periodicals, Inc. <jats:italic>Head Neck<\/jats:italic> 35: 1719\u20131725, 2013<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.23210","type":"journal-article","created":{"date-parts":[[2013,3,8]],"date-time":"2013-03-08T08:51:14Z","timestamp":1362732674000},"page":"1719-1725","source":"Crossref","is-referenced-by-count":23,"title":["Endoglin (CD105) expression on microvessel endothelial cells in juvenile nasopharyngeal angiofibroma: Tissue microarray analysis and association with prognostic significance"],"prefix":"10.1002","volume":"35","author":[{"given":"Jing\u2010Jing","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Eye, Ear, Nose, and Throat Hospital, Shanghai Medical College, Fudan University Shanghai People's Republic of 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