{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T17:29:22Z","timestamp":1760549362180},"reference-count":45,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2013,3,18]],"date-time":"2013-03-18T00:00:00Z","timestamp":1363564800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Studies concerning prognostic factors specific for alendronate\u2010related osteonecrosis of the jaws (ONJ) are rare.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We surveyed a cohort of 100 osteoporotic patients with 111 alendronate\u2010related ONJ lesions treated during a 4\u2010year period. Prognostic values of clinical variables and serum markers of bone turnover were assessed by univariate and multivariate analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The cumulative complete response rate at 6 months was 48.65%. Serum bone\u2010specific alkaline phosphatase (BSAP) level &gt;10 \u03bcg\/L, lesion depth \u2266 10 mm, and lesions in anterior regions denoted a better chance of healing within 6 months and the adjusted hazard ratios were 2.48 (95% confidence interval [CI], 1.41\u20134.37), 2.71 (95% CI, 1.57\u20134.70), and 3.94 (95% CI, 1.87\u20138.30), respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Early discovery of lesions and prevention of their deeper extension are crucial for improving the prognosis of alendronate\u2010related ONJ. A higher pretreatment level of BSAP indicates a better prognosis. \u00a9 2013 Wiley Periodicals, Inc. <jats:italic>Head Neck<\/jats:italic> 35: 1787\u20131795, 2013<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.23235","type":"journal-article","created":{"date-parts":[[2013,3,18]],"date-time":"2013-03-18T17:15:44Z","timestamp":1363626944000},"page":"1787-1795","source":"Crossref","is-referenced-by-count":14,"title":["Factors predicting the prognosis of oral alendronate\u2010related osteonecrosis of the jaws: A 4\u2010year cohort study"],"prefix":"10.1002","volume":"35","author":[{"given":"Jang\u2010Jaer","family":"Lee","sequence":"first","affiliation":[{"name":"School of Dentistry National Taiwan University Medical Center Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shih\u2010Jung","family":"Cheng","sequence":"additional","affiliation":[{"name":"School of Dentistry National Taiwan University Medical Center Taipei 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