{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T22:25:52Z","timestamp":1787610352074,"version":"build-2736575974"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,6,14]],"date-time":"2013-06-14T00:00:00Z","timestamp":1371168000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Mucoepidermoid carcinoma (MEC) is an uncommon malignancy. To the best of our knowledge, this is the largest study investigating disease\u2010specific survival (DSS) of parotid MEC and the first population\u2010level study of the distribution of nodal metastases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients with MEC of the parotid gland were identified in the Surveillance, Epidemiology, and End Results (SEER) database (1988\u20132009).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We identified 2400 patients with MEC: 522 low grade, 1137 intermediate grade, and 741 high grade. Five\u2010year DSS rates for low\u2010grade, intermediate\u2010grade, and high\u2010grade MEC were 98.8%, 97.4%, and 67.0%, respectively (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; .001). Negative prognostic factors included high grade, increasing patient age, and tumor size, extraparenchymal extension, nodal metastases, and distant metastases. High\u2010grade MEC was more likely to have lymph node metastases in levels I to III (34.0%) than low\u2010grade (3.3%) and intermediate\u2010grade MEC (8.1%;\n                      <jats:italic>p<\/jats:italic>\n                      &lt; .001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Grade influences the prognosis and distribution of nodal metastases. Results indicate that management guidelines should vary based on grade. \u00a9 2013 Wiley Periodicals, Inc.\n                      <jats:italic>Head Neck<\/jats:italic>\n                      36: 158\u2013163, 2014\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hed.23256","type":"journal-article","created":{"date-parts":[[2013,6,14]],"date-time":"2013-06-14T04:29:02Z","timestamp":1371184142000},"page":"158-163","source":"Crossref","is-referenced-by-count":115,"title":["Histologic grade as prognostic indicator for mucoepidermoid carcinoma: A population\u2010level analysis of 2400 patients"],"prefix":"10.1002","volume":"36","author":[{"given":"Michelle M.","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Surgery Yale University School of Medicine New Haven Connecticut"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanziana A.","family":"Roman","sequence":"additional","affiliation":[{"name":"Department of Surgery Duke University School of Medicine Durham North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie A.","family":"Sosa","sequence":"additional","affiliation":[{"name":"Department of Surgery Duke University School of Medicine Durham North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin L.","family":"Judson","sequence":"additional","affiliation":[{"name":"Department of Surgery Yale University School of Medicine New Haven Connecticut"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,6,14]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10006-012-0350-9"},{"key":"e_1_2_5_3_1","first-page":"430","volume-title":"Pathology and genetics of head and neck tumours","author":"International Academy of Pathology, World Health Organization, International Agency for Research on Cancer","year":"2005"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21706"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2011.03777.x"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-009-0102-9"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.23825"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.26697"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/MLG.0b013e31815a6b0b"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19920415)69:8<2021::AID-CNCR2820690803>3.0.CO;2-7"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21477"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2004.06.017"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2006.11.045"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.128.8.904"},{"key":"e_1_2_5_15_1","unstructured":"National Cancer Institute. Surveillance Epidemiology and End Results (SEER) Program Brochure. Available at:http:\/\/seer.cancer.gov\/about\/factsheets\/SEER_brochure.pdf. Accessed September 13 2012."},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.134.5.536"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19980401)82:7<1217::AID-CNCR2>3.0.CO;2-C"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1080\/003655402\/000028047"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348949009901015"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200107000-00001"},{"key":"e_1_2_5_21_1","unstructured":"National Comprehensive Cancer Network. Head and Neck Cancers Version 1.2012. Available at:http:\/\/www.nccn.org\/professionals\/physician_gls\/pdf\/head\u2010and\u2010neck.pdf. 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