{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T00:55:07Z","timestamp":1771548907291,"version":"3.50.1"},"reference-count":54,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,5,4]],"date-time":"2013-05-04T00:00:00Z","timestamp":1367625600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The purpose of this study was to investigate the influence of diabetes and corticotherapy on the development of osteonecrosis of the jaws associated with sodium alendronate.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Rats were allocated into 4 groups of 11 animals each, representing different treatments: (1) alendronate; (2) alendronate and corticotherapy; (3) alendronate and diabetes; and (4) control. Tooth extractions were performed in all animals, and histological analysis was performed by hematoxylin and eosin staining and immunohistochemistry using anti\u2010bone morphogenetic protein (BMP)\u20104 and anti\u2010matrix metalloproteinase (MMP)\u201013 antibodies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>On hematoxylin and eosin analysis, proportions of inflammatory infiltrate, microbial colonies, and osteonecrosis were significantly greater in the diabetes group. BMP\u20104 expression in connective tissue was higher in the corticosteroid group than the alendronate group. There were no significant differences between the other groups. MMP\u201013 expression did not differ between the groups analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Diabetes but not corticotherapy is associated with jaw osteonecrosis in rats undergoing alendronate therapy and subjected to tooth extractions. \u00a9 2013 Wiley Periodicals, Inc. <jats:italic>Head Neck<\/jats:italic> <jats:bold>36<\/jats:bold>: 84\u201393, 2014<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.23260","type":"journal-article","created":{"date-parts":[[2013,5,4]],"date-time":"2013-05-04T16:56:37Z","timestamp":1367686597000},"page":"84-93","source":"Crossref","is-referenced-by-count":31,"title":["Diabetes mellitus and corticotherapy as risk factors for alendronate\u2010related osteonecrosis of the jaws: A study in Wistar rats"],"prefix":"10.1002","volume":"36","author":[{"given":"Soraya A.","family":"Berti\u2013Couto","sequence":"first","affiliation":[{"name":"Dental College Pontifical Catholic University of Rio Grande do Sul Hospital S\u00e3o Lucas Porto Alegre RS Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Carolina U.","family":"Vasconcelos","sequence":"additional","affiliation":[{"name":"Dental College Pontifical Catholic University of Rio Grande do Sul Hospital S\u00e3o Lucas Porto Alegre RS Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00falia E.","family":"Iglesias","sequence":"additional","affiliation":[{"name":"Dental College Pontifical Catholic University of Rio Grande do Sul Porto Alegre RS Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Antonia Z.","family":"Figueiredo","sequence":"additional","affiliation":[{"name":"Dental College Pontifical Catholic University of Rio Grande do Sul Hospital S\u00e3o Lucas Porto Alegre RS Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernanda G.","family":"Salum","sequence":"additional","affiliation":[{"name":"Dental College Pontifical Catholic University of Rio Grande do Sul Hospital S\u00e3o Lucas Porto Alegre RS Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen","family":"Cherubini","sequence":"additional","affiliation":[{"name":"Dental College Pontifical Catholic University of Rio Grande do Sul Hospital S\u00e3o Lucas Porto Alegre RS Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,5,4]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000187398.51857.3c"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cden.2007.09.002"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-144-10-200605160-00009"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0278-2391(03)00720-1"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2010.02.037"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2009.01.009"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2010.11.002"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s100670050116"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21422"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.1983.tb00331.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/ortho\/25.2.101"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.449"},{"key":"e_1_2_7_14_1","first-page":"1277","article-title":"Bone metabolic abnormality in diabetes: especially about osteoblast dysfunction. 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