{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,29]],"date-time":"2025-11-29T16:15:03Z","timestamp":1764432903641},"reference-count":17,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,4,4]],"date-time":"2013-04-04T00:00:00Z","timestamp":1365033600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Current literature on the effect of postoperative complications on survival outcomes in head and neck cancers remains contradictory. This study assesses whether postoperative complications adversely affect survival in cases of complex surgical ablation and reconstruction of oral squamous cell carcinoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In all, 255 consecutive patients with complete clinicopathologic data were included. Survival was determined using the log\u2010rank test and Kaplan\u2013Meier survival curves were generated. A Cox proportional hazards model was used to adjust for the effect of other significant covariates to determine the independent effect of complication variables for overall survival (OS). A competing risk model was used for disease\u2010specific survival (DSS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>On multivariable analysis, major complications independently prognosticated for reduced OS [hazard ratio (HR) 2.4, 95% confidence interval (CI) 1.1\u20133.2, <jats:italic>p<\/jats:italic> = .02]. There was no evidence for an association between any complication\u2010variable and DSS or recurrence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Major postoperative complications are independently associated with decreased OS. \u00a9 2013 Wiley Periodicals, Inc. <jats:italic>Head Neck<\/jats:italic> <jats:bold>36<\/jats:bold>: 55\u201359, 2014<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.23266","type":"journal-article","created":{"date-parts":[[2013,4,4]],"date-time":"2013-04-04T13:26:41Z","timestamp":1365082001000},"page":"55-59","source":"Crossref","is-referenced-by-count":20,"title":["Relationship between postoperative complications and survival after free flap reconstruction for oral cavity squamous cell carcinoma"],"prefix":"10.1002","volume":"36","author":[{"given":"Sydney","family":"Ch'ng","sequence":"first","affiliation":[{"name":"Sydney Head and Neck Cancer Institute Royal Prince Alfred Hospital Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincent","family":"Choi","sequence":"additional","affiliation":[{"name":"Sydney Head and Neck Cancer Institute Royal Prince Alfred Hospital Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Elliott","sequence":"additional","affiliation":[{"name":"Sydney Head and Neck Cancer Institute Royal Prince Alfred Hospital Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan R.","family":"Clark","sequence":"additional","affiliation":[{"name":"Sydney Head and Neck Cancer Institute Royal Prince Alfred Hospital Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,4,4]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.20735"},{"key":"e_1_2_6_3_1","first-page":"828","article-title":"Risk factors for postoperative complications in oral cancer and their prognostic implications","volume":"127","author":"Melo GM","year":"2001","journal-title":"Arch Otolaryngol Head Neck Surg"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.129.2.219"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/019459988008800417"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19921015)70:8<2166::AID-CNCR2820700826>3.0.CO;2-H"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21866"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0194-5998(98)80030-2"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1992.01880050032007"},{"key":"e_1_2_6_10_1","first-page":"700","article-title":"The cytotoxic effects of hemolytic streptococci on ascites tumor cells","volume":"23","author":"Havas HF","year":"1963","journal-title":"Cancer Res"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1989.01860350056015"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6604004"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02552653"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10350-004-6174-4"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature01322"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2008.09.038"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2004.09.015"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3800474"}],"container-title":["Head &amp; Neck"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhed.23266","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.23266","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T02:37:47Z","timestamp":1696387067000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hed.23266"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,4,4]]},"references-count":17,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,1]]}},"alternative-id":["10.1002\/hed.23266"],"URL":"https:\/\/doi.org\/10.1002\/hed.23266","archive":["Portico"],"relation":{},"ISSN":["1043-3074","1097-0347"],"issn-type":[{"value":"1043-3074","type":"print"},{"value":"1097-0347","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,4,4]]}}}