{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T16:42:54Z","timestamp":1773160974429,"version":"3.50.1"},"reference-count":9,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,4,4]],"date-time":"2013-04-04T00:00:00Z","timestamp":1365033600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Little is known about the determinants of postradiation neck spasms in patients with head and neck cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with head and neck cancer treated with radiation therapy (RT) from 2004 to 2010 who experienced neck spasms werereviewed. Radiation doses were generated for their sternocleidomastoid (SCM) muscles bilaterally. Unaffected SCMs were used as controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty\u2010four patients reported neck spasms. Thirty had received definitive chemoradiation, and 4 had RT alone. Seven also had an ipsilateral neck dissection. Median time to onset was 23 months (range, 6\u201367 months). There were significantly higher radiation doses to the affected SCMs with a median of the mean dose to the affected and unaffected SCM of 62.3 Gy (range, 29\u201371 Gy) and 53.7 Gy (range, 27\u201365 Gy), respectively (<jats:italic>p<\/jats:italic> &lt; .0001). Other dosimetric variables were also statistically significant but were highly correlated with the mean SCM dose. Neck dissection did not affect our results.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Neck spasms after chemotherapy intensity\u2010modulated radiation therapy (IMRT) shows a strong dose\u2013response relationship. \u00a9 2013 Wiley Periodicals, Inc. <jats:italic>Head Neck<\/jats:italic> 36: 176\u2013180, 2014<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.23284","type":"journal-article","created":{"date-parts":[[2013,4,4]],"date-time":"2013-04-04T13:26:53Z","timestamp":1365082013000},"page":"176-180","source":"Crossref","is-referenced-by-count":10,"title":["Neck spasm after chemoradiotherapy for head and neck cancer: Natural history and dosimetric correlates"],"prefix":"10.1002","volume":"36","author":[{"given":"Klaudia U.","family":"Hunter","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology University of Michigan Ann Arbor Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francis","family":"Worden","sequence":"additional","affiliation":[{"name":"Department Hematology\u2013Oncology University of Michigan Ann Arbor Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carol","family":"Bradford","sequence":"additional","affiliation":[{"name":"Department Otolaryngology\u2013Head Neck Surgery University of Michigan Ann Arbor Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Prince","sequence":"additional","affiliation":[{"name":"Department Otolaryngology\u2013Head Neck Surgery University of Michigan Ann Arbor Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott","family":"McLean","sequence":"additional","affiliation":[{"name":"Department Otolaryngology\u2013Head Neck Surgery University of Michigan Ann Arbor Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory","family":"Wolf","sequence":"additional","affiliation":[{"name":"Department Otolaryngology\u2013Head Neck Surgery University of Michigan Ann Arbor Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Douglas B.","family":"Chepeha","sequence":"additional","affiliation":[{"name":"Department Otolaryngology\u2013Head Neck Surgery University of Michigan Ann Arbor Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Avraham","family":"Eisbruch","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology University of Michigan Ann Arbor Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,4,4]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2007.02.049"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.128.8.956"},{"key":"e_1_2_5_4_1","doi-asserted-by":"crossref","unstructured":"GelblumD WoldenS SchupakK LeeN. Neck spasms as a late effect of intensity modulated radiation therapy (IMRT) for head and neck cancer. Available at:http:\/\/astro2011.abstractsnet.com\/pdfs\/2708.pdf. 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