{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,29]],"date-time":"2026-03-29T21:23:52Z","timestamp":1774819432474,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,6,14]],"date-time":"2013-06-14T00:00:00Z","timestamp":1371168000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The purpose of this systematic review and meta\u2010analysis was to assess the oncological and functional outcomes of transoral laser microsurgery (TLM) in radiorecurrent laryngeal cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The review was performed using search strategies including Medline, Embase, Zetoc, conference proceedings, and a manual search. Pooled estimates of local control at 24 months, disease\u2010free survival (DFS), and overall survival (OS) rates were calculated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The pooled mean estimates were: local control rate at 24 months after first TLM (<jats:italic>n<\/jats:italic> = 249), 56.9% (95% confidence interval [CI], 47.4\u201366.1); local control after repeat TLM (<jats:italic>n<\/jats:italic> = 186), 63.8% (95% CI, 57.1\u201370.2); DFS (<jats:italic>n<\/jats:italic> = 174), 70.9% (95% CI, 60.8\u201380); and OS (<jats:italic>n<\/jats:italic> = 276), 74.8% (95% CI, 68.2\u201380.9). Pooled mean laryngeal preservation (<jats:italic>n<\/jats:italic> = 286) was 72.3% (95% CI, 68.4\u201376.1).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>TLM is oncologically sound in the salvage setting with high larynx\u2010preservation rate, but there is a trend toward inferior local control rates compared to open partial laryngectomy techniques. \u00a9 2013 Wiley Periodicals, Inc. <jats:italic>Head Neck<\/jats:italic> 36: 280\u2013285, 2014<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.23291","type":"journal-article","created":{"date-parts":[[2013,6,14]],"date-time":"2013-06-14T08:30:53Z","timestamp":1371198653000},"page":"280-285","source":"Crossref","is-referenced-by-count":38,"title":["Oncologic outcomes of transoral laser microsurgery for radiorecurrent laryngeal carcinoma: A systematic review and meta\u2010analysis of English\u2010language literature"],"prefix":"10.1002","volume":"36","author":[{"given":"Yujay","family":"Ramakrishnan","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2010 Head and Neck Surgery The Newcastle upon Tyne Hospitals NHS Foundation Trust Newcastle upon Tyne United Kingdom"},{"name":"Department of Otolaryngology\u2010 Head and Neck Surgery Nottingham University Hospitals NHS Trust Nottingham United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mike","family":"Drinnan","sequence":"additional","affiliation":[{"name":"Department of Medical Physics The Newcastle upon Tyne Hospitals NHS Foundation Trust Newcastle upon Tyne United Kingdom"},{"name":"Department of Otolaryngology\u2010 Head and Neck Surgery Nottingham University Hospitals NHS Trust Nottingham United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Foon Ng Kee","family":"Kwong","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010 Head and Neck Surgery The Newcastle upon Tyne Hospitals NHS Foundation Trust Newcastle upon Tyne United Kingdom"},{"name":"Department of Otolaryngology\u2010 Head and Neck Surgery Nottingham University Hospitals NHS Trust Nottingham United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David G.","family":"Grant","sequence":"additional","affiliation":[{"name":"Department of Medical Physics The Newcastle upon Tyne Hospitals NHS Foundation Trust Newcastle upon Tyne United Kingdom"},{"name":"Department of Otolaryngology\u2010 Head and Neck Surgery Nottingham University Hospitals NHS Trust Nottingham United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hisham","family":"Mehanna","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010 Head and Neck Surgery Nottingham University Hospitals NHS Trust Nottingham United Kingdom"},{"name":"School of Cancer Sciences and Institute of Head and Neck Studies and Education University of Birmingham Birmingham United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Terry","family":"Jones","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010 Head and Neck Surgery Nottingham University Hospitals NHS Trust Nottingham United Kingdom"},{"name":"Liverpool CR\u2010UK Centre Department of Molecular and Clinical Cancer Medicine University of Liverpool United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vinidh","family":"Paleri","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010 Head and Neck Surgery The Newcastle upon Tyne Hospitals NHS Foundation Trust Newcastle upon Tyne United Kingdom"},{"name":"Department of Otolaryngology\u2010 Head and Neck Surgery Nottingham University Hospitals NHS Trust Nottingham United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,6,14]]},"reference":[{"key":"e_1_2_6_2_1","volume-title":"Part V. 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