{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T16:00:39Z","timestamp":1783958439957,"version":"3.55.0"},"reference-count":17,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,6,1]],"date-time":"2013-06-01T00:00:00Z","timestamp":1370044800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The purpose of this study was to determine whether indeterminate pulmonary nodules (IPNs) at staging are predictive of lung metastasis, primary lung carcinoma, or survival in patients with advanced head and neck squamous cell carcinoma (HNSCC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>One hundred ten patients with IPN at staging who had follow\u2010up imaging and 100 patients without IPN were identified from an HNSCC database. The primary endpoints were lung progression\u2010free survival (PFS) and overall survival (OS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Two\u2010year lung PFS for the IPN and No\u2010IPN cohorts were 66% versus 61% (\n                      <jats:italic>p<\/jats:italic>\n                      = .92) and the OS for these cohorts were 71% versus 68% (\n                      <jats:italic>p<\/jats:italic>\n                      = .77). Within the IPN cohort, level IV\/V lymph node involvement (odds ratio = 4.34;\n                      <jats:italic>p<\/jats:italic>\n                      = .03), hypopharynx primary (odds ratio = 21.5;\n                      <jats:italic>p<\/jats:italic>\n                      = .005), and race (odds ratio = 9.29;\n                      <jats:italic>p<\/jats:italic>\n                      = .001) were independent predictors of developing lung malignancy.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      IPNs at staging in patients with HNSCC do not affect prognosis and should neither influence initial treatment planning nor the frequency of posttreatment surveillance. \u00a9 2013 Wiley Periodicals, Inc.\n                      <jats:italic>Head Neck<\/jats:italic>\n                      <jats:bold>36<\/jats:bold>\n                      : 334\u2013339, 2014\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hed.23294","type":"journal-article","created":{"date-parts":[[2013,6,1]],"date-time":"2013-06-01T03:52:40Z","timestamp":1370058760000},"page":"334-339","source":"Crossref","is-referenced-by-count":5,"title":["Clinical significance of indeterminate pulmonary nodules in patients with locally advanced head and neck squamous cell carcinoma"],"prefix":"10.1002","volume":"36","author":[{"given":"Raphael E.","family":"Alford","sequence":"first","affiliation":[{"name":"Department of Radiology University of North Carolina Hospitals Chapel Hill North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David V.","family":"Fried","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology University of North Carolina Hospitals Chapel Hill North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin Y.","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Radiology University of North Carolina Hospitals Chapel Hill North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Weissler","sequence":"additional","affiliation":[{"name":"Otolaryngology\/Head and Neck Surgery Chapel Hill University of North Carolina Hospitals Chapel Hill North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carol","family":"Shores","sequence":"additional","affiliation":[{"name":"Otolaryngology\/Head and Neck Surgery Chapel Hill University of North Carolina Hospitals Chapel Hill North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Shockley","sequence":"additional","affiliation":[{"name":"Otolaryngology\/Head and Neck Surgery Chapel Hill University of North Carolina Hospitals Chapel Hill North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trevor","family":"Hackman","sequence":"additional","affiliation":[{"name":"Otolaryngology\/Head and Neck Surgery Chapel Hill University of North Carolina Hospitals Chapel Hill North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Zanation","sequence":"additional","affiliation":[{"name":"Otolaryngology\/Head and Neck Surgery Chapel Hill University of North Carolina Hospitals Chapel Hill North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil","family":"Hayes","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology University of North Carolina Hospitals Chapel Hill North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jared","family":"Weiss","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology University of North Carolina Hospitals Chapel Hill North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juneko","family":"Grilley\u2013Olson","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology University of North Carolina Hospitals Chapel Hill North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerie","family":"Jewells","sequence":"additional","affiliation":[{"name":"Department of Radiology University of North Carolina Hospitals Chapel Hill North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine","family":"Birchard","sequence":"additional","affiliation":[{"name":"Department of Radiology University of North Carolina Hospitals Chapel Hill North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bhishamjit S.","family":"Chera","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology University of North Carolina Hospitals Chapel Hill North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,6]]},"reference":[{"key":"e_1_2_5_2_1","unstructured":"National Comprehensive Cancer Network. 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